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US 10,160,738 B2Granted
Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
AssigneeWashington University
InventorDouglas Covey
Life of this patent
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Abstract
The present disclosure is generally directed to neuroactive substituted cyclopent[a]anthracenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
Claims6
A compound of Formula (II-a):
- wherein R2 is H, ═O, ═CHCN, ═CHCO2Rw, where Rw is optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkenyl, or optionally substituted C2-C4 alkynyl, α-CN, α-OH, α-ORv, where Rv is optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkenyl, or optionally substituted C2-C4 alkynyl, α-NO2, spiroepoxy, or C(O)Ru, where Ru is optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkenyl, or optionally substituted C2-C4 alkynyl;
- R3 is H, ═O, ═CHCN, ═CHCO2Rt, where Rt is optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkenyl, or optionally substituted C2-C4 alkynyl, —CN, α-OH, α-ORs, where Rs is optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkenyl, or optionally substituted C2-C4 alkynyl, α-NO2, spiroepoxy, or C(O)Rr, where Rr is optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkenyl, or optionally substituted C2-C4 alkynyl;
- and,
- - - - denotes an optional C—C bond, resulting in a C═C bond between C2-C3.
1 more element
Dependencies are inferred from the claim text.