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US 10,155,790 B2Granted
Antagonists of neurokinin B in fish reproduction
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsBerta Levavi-Sivan, Chaim Gilon
Life of this patent
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Abstract
Provided are Peptide-based neurokinin antagonists of fish reproduction. Compositions including antagonists of fish neurokinin and methods of inhibiting or delaying puberty, fish maturation or reproduction processes using these compounds are also provided.
Claims20
A peptidomimetic according to formula I:
- X1-NMeVal-X4-Leu-Met-Z (Formula I), wherein:
- the peptidomimetic consists of 5-10 amino acids;
- X1 is a stretch of 1-6 natural or non-natural amino acid residues and optionally an N-terminal capping moiety or modification;
- NMeVal is an N-methyl-Valine residue or N-methyl-D-Valine residue;
- X4 is —NH(CH2)n-CO— wherein n is 2-6;
- and
- Z represents the C-terminus of the peptide which may be amidated, acylated, reduced or esterified.
4 more elements
Dependencies are inferred from the claim text.