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US 10,155,777 B2Granted
Trans-cycloheptenes and hetero-trans-cycloheptenes for bioorthogonal coupling
AssigneeUniversity of Delaware
InventorsJoseph Fox, Han Zhang, Yinzhi Fang
Life of this patent
Estimating the term…
Abstract
A substituted trans-cycloheptene according to formula (I); wherein: a) Z and L are each selected from the group consisting of SiR1R2, CH2, CHOH, and CHR2; R1 is phenyl or CH3; R2 is phenyl, CH3, (CH2)nCN, or (CH2)nOH, wherein n is an integer from 1 to 5; Ra and Rb are each individually selected from the group consisting of H, OH, and CH3; and Z and L are not both SiR1R2; or b) Z is BocN, L is CH2, Ra is H, and Rb is H; or c) Z is C=0, L is CH2, Ra is H, and Rb is H.
Claims3
A substituted trans-cycloheptene according to formula (I)
- wherein:
- a) Z and L are each selected from the group consisting of SiR1R2, CH2, CHOH, and CHR2;
- R1 is phenyl or CH3;
- R2 is phenyl, CH3, (CH2)nCN, or (CH2)nOH, wherein n is an integer from 1 to 5;
- Ra and Rb are each individually selected from the group consisting of H, OH, and CH3;
- and Z and L are not both SiR1R2;
- or
- b) Z is BocN, L is CH2, Ra is H, and Rb is H;
- or
- c) Z is C═O, L is CH2, Ra is H, and Rb is H.
7 more elements
Dependencies are inferred from the claim text.