Influenza antigen delivery vectors and constructs
AssigneeAltimmune UK Limited
InventorsDominique Bonnet, Carlton B. Brown, Bertrand V. Georges, Philip J. Sizer
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Abstract
The present invention relates to fluorocarbon vectors for the delivery of influenza antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-influenza antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals, including humans.
Claims15
A vector-antigen construct comprising:
- an antigenic influenza peptide sequence covalently attached to a vector, wherein the vector is of structure CmXn—CyHx-(Sp)-R, wherein m=3 to 30, n<=2m+1, y=0 to 15, x<=2y, (m+y)=3 to 30, Sp is an optional chemical spacer moiety, R is the antigenic influenza peptide and X is selected from a fluorine, chlorine, bromine or iodine, and wherein the antigenic influenza peptide is up to 40 amino acids in length and comprises any one of SEQ ID NOs:
- 1 to 65.
A pharmaceutical composition for intracellular delivery of an antigen, the composition comprising an antigenic influenza peptide sequence covalently attached to a vector, wherein the vector is of structure CmXn—CyHx-(Sp)-R, wherein m=3 to 30, n<=2m+1, y=0 to 15, x<=2y, (m+y)=3 to 30, Sp is an optional chemical spacer moiety, R is the antigenic influenza peptide and X is selected from a fluorine, chlorine, bromine or iodine, and wherein the antigenic influenza peptide is up to 40 amino acids in length and comprises any one of SEQ ID NOs:
- 1 to 65.
Dependencies are inferred from the claim text.