Method for prophylaxis and/or treatment of ErbB2 positive cancers
AssigneeHealth Research, Inc.
InventorsYuesheng Zhang, Lu Yang, Yun Li
Life of this patent
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Abstract
Provided are compositions and methods for prophylaxis and/or therapy of ErbB2-positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase D (PEPD) proteins. The methods include prophylaxis and/or therapy of ErbB2-positive cancer by administering a PEPD to an individual who has or is at risk for developing ErbB2-positive cancer.
Claims6
A method for therapy of ErbB2-positive cancer in an individual, the method comprising selecting an individual for the therapy based on a determination of ErbB-2 positive cancer cells in a sample of a tumor from the individual, and subsequently inhibiting the growth of the tumor by administering to the individual an effective amount of a composition comprising peptidase D (PEPD) comprising a mutation of glycine at position 278 of SEQ ID NO:1, such that growth of the ErbB2-positive tumor is inhibited.
Dependencies are inferred from the claim text.