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US 10,154,951 B2Granted
Cross linked silk-hyaluronic acid composition
AssigneeAllergan, Inc.
InventorsElizabeta Pavlovic, Monica A. Serban, Xiaojie Yu, Nicholas J. Manesis
Life of this patent
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Abstract
Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.
Claims8
A process for making an injectable composition for treating a soft tissue condition, the process comprising:
- (a) activating a hyaluronic acid using a carbodiimide coupling agent, and
- (b) cross linking the activated hyaluronic acid to silk using a multiamine cross linker whereby the silk is crosslinked to the hyaluronic acid via amide bonding to the multiamine cross linker.
Dependencies are inferred from the claim text.