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US 10,151,762 B2Granted
Bacteriophage gene 3 protein compositions and use as amyloid binding agents
AssigneeProclara Biosciences, Inc.
InventorsRajaraman Krishnan, Richard Fisher
Life of this patent
Estimating the term…
Abstract
The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.
Claims12
A nucleic acid encoding a fusion protein that consists essentially of an amyloid-binding polypeptide linked directly or through a short peptide linker to an immunoglobulin IgG constant region, wherein the amyloid-binding polypeptide comprises at least one of:
- (a) a wild type gene 3 protein (g3p) or a mutant thereof that retains the ability to bind to amyloid, or
- (b) an amyloid-binding fragment of wild type g3p, or a mutant thereof that retains the ability to bind to amyloid.
Dependencies are inferred from the claim text.