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US 10,150,841 B2Granted
Chromophoric polymer dots with narrow-band emission
AssigneeUniversity of Washington through its Center for Commercialization
InventorsDaniel T. Chiu, Changfeng Wu, Yu Rong, Yong Zhang, Yi-Che Wu, Yang-Hsiang Chan, Xuanjun Zhang, Jiangbo Yu, Wei Sun
Life of this patent
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Abstract
Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
Claims68
A polymer dot comprising:
- a condensed chromophoric polymer comprising a semiconducting polymer, wherein the semiconducting polymer comprises a narrow-band emissive monomer, the condensed chromophoric polymer having an emission spectrum with a full width half maximum (FWHM) of less than about 70 nm, and wherein the ratio of the number of narrow-band emissive monomers to the number of other monomers is about 1:20 or less.
A polymer dot comprising:
- a condensed chromophoric polymer comprising a semiconducting polymer, wherein the semiconducting polymer comprises a narrow-band unit attached to the backbone or a sidechain of the polymer, wherein the narrow-band unit comprises an emission spectrum with a full width half maximum (FWHM) of less than about 70 nm, wherein the backbone comprises a first general monomer, a second general monomer, or a combination thereof, wherein the narrow-band unit comprises a narrow-band emissive monomer, and wherein the ratio of the number of narrow-band emissive monomers to the number of other monomers is about 1:20 or less.
A method of making a polymer dot, the method comprising:
- providing a solvent solution comprising a chromophoric polymer, the chromophoric polymer being in an elongated coil form and comprising a semiconducting polymer, wherein the semiconducting polymer comprises a narrow-band emissive monomer, wherein the chromophoric polymer comprises an emission spectrum with a full width half maximum (FWHM) of greater than about 70 nm, and wherein the ratio of the number of narrow-band emissive monomers to the number of other monomers is about 1:20 or less;
- and
- mixing the solvent solution comprising the chromophoric polymer with a miscible solvent to form a condensed chromophoric polymer, wherein the condensed chromophoric polymer comprises an emission spectrum with a FWHM less than about 70 nm.
A method of making a polymer dot, the method comprising:
- providing a solvent solution comprising a chromophoric polymer, the chromophoric polymer being in an elongated coil form and comprising a semiconducting polymer, wherein the semiconducting polymer comprises a narrow-band emissive monomer, wherein the chromophoric polymer comprises an emission spectrum with a full width half maximum (FWHM) of less than about 70 nm, and wherein the ratio of the number of narrow-band emissive monomers to the number of other monomers is about 1:20 or less;
- and
- mixing the solvent solution comprising the chromophoric polymer with a miscible solvent to form a condensed chromophoric polymer, wherein the condensed chromophoric polymer comprises an emission spectrum with a FWHM less than about 70 nm.
A method of multiplex detection with a polymer dot, the method comprising:
- detecting the polymer dot with a detector system comprising a filter configured to pass a spectrum of light having a full width half maximum (FWHM) of less than about 70 nm, wherein the polymer dot comprises a condensed chromophoric polymer comprising a semiconducting polymer, wherein the semiconducting polymer comprises a narrow-band emissive monomer, the condensed chromophoric polymer having an emission spectrum with a full width half maximum (FWHM) of less than about 70 nm, and wherein the ratio of the number of narrow-band emissive monomers to the number of other monomers is about 1:20 or less.
A method of making a polymer dot, the method comprising:
- providing a solvent solution comprising a chromophoric polymer, the chromophoric polymer being in an elongated coil form and comprising a semiconducting polymer, wherein the semiconducting polymer comprises a narrow-band unit attached to the backbone or a sidechain of the polymer, wherein the narrow-band unit comprises an emission spectrum with a full width half maximum (FWHM) of greater than about 70 nm, wherein the narrow-band unit comprises a narrow-band emissive monomer, and wherein the ratio of the number of narrow-band emissive monomers to the number of other monomers is about 1:20 or less;
- and
- mixing the solvent solution comprising the chromophoric polymer with a miscible solvent to form a condensed chromophoric polymer, wherein the condensed chromophoric polymer comprises an emission spectrum with a FWHM less than about 70 nm.
A method of making a polymer dot, the method comprising:
- providing a solvent solution comprising a chromophoric polymer, the chromophoric polymer being in an elongated coil form and comprising a semiconducting polymer, wherein the semiconducting polymer comprises a narrow-band unit attached to the backbone or a sidechain of the polymer, wherein the narrow-band unit comprises an emission spectrum with a full width half maximum (FWHM) of less than about 70 nm, wherein the narrow-band unit comprises a narrow-band emissive monomer, and wherein the ratio of the number of narrow-band emissive monomers to the number of other monomers is about 1:20 or less;
- and
- mixing the solvent solution comprising the chromophoric polymer with a miscible solvent to form a condensed chromophoric polymer, wherein the condensed chromophoric polymer comprises an emission spectrum with a FWHM less than about 70 nm.
Dependencies are inferred from the claim text.