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US 10,150,798 B2Granted
Desmoglein 2 (DSG2) binding proteins and uses therefor
AssigneeUniversity of Washington through its Center for Commercialization
InventorsAndre Lieber, Hongjie Wang
Life of this patent
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Abstract
The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.
Claims20
A recombinant AdB-2/3 fiber polypeptide homotrimer, wherein each member of the homotrimer comprises:
- (a) one or more AdB-2/3 fiber polypeptide shaft domain motifs;
- (b) an AdB-2/3 fiber polypeptide knob domain operatively linked to and located C-terminal to the one or more AdB-2/3 fiber polypeptide shaft domain motifs, wherein the AdB-2/3 fiber polypeptide knob domain comprises the peptide of SEQ ID NO:4 wherein:
- X2 is H, L, or P;
- X3 is K or E;
- X4 is T, F, S, or L;
- X5 is V, or D;
- X6 is E or G;
- X7 is Y or F;
- X8 is T, K, or E;
- and X9 is N or S;
- and wherein at least one of the following is true:
- X2 is P;
- X3 is E;
- X4 is S, or L;
- X5 is D;
- X6 is G;
- X7 is F;
- X8 is E;
- or X9 is S;
- and (c) one or more non-AdB-2/3-derived dimerization domains operatively linked to and located N-terminal to the one or more AdB-2/3 fiber polypeptide shaft domain motifs.
17 more elements
Dependencies are inferred from the claim text.