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AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), Universite De Bordeaux
InventorsPier Vincenzo Piazza, Monique Vallee, Giovanni Marsicano, Francois-Xavier Felpin, Luigi Bellocchio, Daniela Cota, Jean-Michel Revest, Sergio Vitiello, Umberto Spampinato, Rafael Maldonado
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The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders; inflammatory diseases; cardiovascular diseases; nephropathies; glaucoma; spasticity; cancer; osteoporosis; metabolic disorders; obesity; addiction, dependence, abuse and relapse related disorders; psychiatric and neurological disorders; neurodegenerative disorders; autoimmune hepatitis and encephalitis; pain; reproductive disorders and skin inflammatory and fibrotic diseases.
A pregnenolone derivative wherein said pregnenolone derivative is 17α-Benzyl-3β-fluoropregnenolone, 17α-Benzyl-3β-benzyloxypregnenolone, 3β-Benzyloxy-17α-methylpregnenolone, 17α-Benzylpregnenolone, 3β-Methoxy-17α-methylpregnenolone, 17α-Allyl-3β-methoxypregnenolone or 17α-Benzyl-3β-methoxypregnenolone.
Dependencies are inferred from the claim text.