Isoxazole derivatives as FXR agonists and methods of use thereof

A compound represented by Formula I or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 is an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, or optionally substituted —C3-C8 cycloalkyl;
• R2 is hydrogen, halogen, cyano, optionally substituted —C1-C6 alkyl, optionally substituted —C2-C6 alkenyl, optionally substituted —C2-C6 alkynyl, optionally substituted —C3-C6 cycloalkyl or optionally substituted 3- to 6-membered heterocycloalkyl;
• A is optionally substituted aryl or optionally substituted heteroaryl;
• R3 is
• R4 and R5 are independently selected from the group consisting of:
• 1) Hydrogen;
• 2) Optionally substituted —C1-C8 alkyl;
• 3) Optionally substituted —C2-C8 alkenyl;
• 4) Optionally substituted —C2-C8 alkynyl;
• and
• 5) Optionally substituted —C3-C8 cycloalkyl;
• R7 is selected from the group consisting of:
• 1) Optionally substituted —C1-C8 alkyl;
• 2) Optionally substituted —C2-C8 alkenyl;
• 3) Optionally substituted —C2-C8 alkynyl;
• 4) Optionally substituted —C3-C8 cycloalkyl;
• 5) Optionally substituted —C3-C8 cycloalkenyl;
• 6) Optionally substituted aryl;
• 7) Optionally substituted arylalkyl;
• 8) Optionally substituted 3- to 8-membered heterocycloalkyl;
• 9) Optionally substituted heteroaryl;
• 10) Optionally substituted heteroarylalkyl;
• and
• 11) NR8R9;
• wherein R5 and R9 are each independently selected from hydrogen, optionally substituted —C1-C8 alkyl, optionally substituted —C2-C8 alkenyl, optionally substituted —C2-C8 alkynyl, optionally substituted —C3-C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted 3- to 8-membered heterocycloalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, alternatively, R8 and R9 are taken together with the nitrogen atom to which they are attached to form an optionally substituted heterocyclic ring.