Multi-component nanochains
AssigneeCase Western Reserve University
InventorsEfstathios Karathanasis, Watuthantrige Pubudu M Peiris, Mark Griswold
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Abstract
A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.
Claims18
A system for delivering a therapeutic agent to cells or tissue of a subject or imaging a cell or tissue of a subject;
- the system comprising:
- a multi-component nanochain that includes at least three nanoparticles linked together to form the nanochain by first linkers and different second linkers disposed on surfaces of separate nanoparticles, at least one nanoparticle of the nanochain having asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers that are linked respectively to second linkers and first linkers of the separate nanoparticles, wherein the nanoparticles include a liposome, lipidic nanoparticle, or polymer nanoparticle linked to a metal nanoparticle, and wherein optionally at least one nanoparticle comprising or being linked to a therapeutic agent.
A system for delivering a therapeutic agent to cells or tissue of a subject or imaging a cell or tissue of a subject;
- the system comprising:
- a multi-component nanochain that includes at least three nanoparticles linked together to form the nanochain by first linkers and different second linkers disposed on surfaces of separate nanoparticles, at least one nanoparticle of the nanochain having asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers that are linked respectively to second linkers and first linkers of the separate nanoparticles, the nanochain including at least one targeting moiety linked to a nanoparticle of the nanochain, and wherein optionally at least one nanoparticle comprising or being linked to a therapeutic agent.
Dependencies are inferred from the claim text.