Medical drainage devices with carbon-based structures for inhibiting growth of fibroblasts
AssigneeMobius Therapeutics, LLC
InventorsKhalid Lafdi, Edward J. Timm
Life of this patent
Estimating the term…
Abstract
Drainage devices for draining a fluid from a patient during treatment of a medical condition body are disclosed. The drainage devices comprise a body defining at least one conduit through the body from a distal end of the body to a proximal end of the body. The body comprises at least one carbon-based structure configured to inhibit growth of fibroblasts in the conduit when the fluid flows through the conduit. Example embodiments of the drainage device may include an ophthalmic shunt, a hydrocephalus shunt, an artificial mesh, an arteriovenous shunt, a thoracic catheter, and a central venous access device.
Claims27
A composition for use in manufacturing an implantable medical device, having a body with an opening therethrough defining a fluid path for passage of body fluids therethrough, the composition comprising:
- a carbon scaffold consisting essentially fibers combined with a biocompatible polymer;
- and
- a layer of carbon nanotubes grown on the carbon fibers providing a resulting structure and configured to be provided at least on inner walls defining the body of the implantable medical device, the resulting structure forming a carbon fuzzy veil;
- wherein:
- the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone.
A flexible composite for use in manufacturing an implantable medical device having a body with an opening therethrough defining a fluid path through the body, for passage of body fluids, the body having inner walls facing the opening, the flexible composite comprising:
- a flexible carbon scaffold consisting essentially of carbon fibers combined with a biocompatible polymer;
- and
- a layer of carbon nanotubes grown on the carbon fibers providing a resulting structure and configured to be provided at least on inner walls defining the body of the implantable medical device, the resulting structure forming a carbon fuzzy veil;
- wherein the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone, and wherein the flexible composite is conformal to the inner walls.
A method for inhibiting fibroblast growth associated with the implantation of a medical drainage device in a subject, wherein the medical drainage device comprises a body having an opening defining a fluid path therethrough and inner walls configured for communication with body fluids passing through the opening, the method comprising:
- coating at least the inner walls of the medical drainage device with a composition comprising:
- a carbon scaffold consisting essentially of carbon fibers combined with a biocompatible polymer;
- and
- a layer of carbon nanotubes grown on the carbon fibers providing a resulting structure and configured to be provided at least on inner walls defining the body of the implantable medical device, the resulting structure forming a carbon fuzzy veil,
- wherein the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone.
Dependencies are inferred from the claim text.