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US 10,137,208 B2Granted
Vivo tumor targeting and spectroscopic detection with surface-enhanced raman nanoparticle tags
AssigneeEmory University
InventorsXimei Qian, Dominic Ansari, Shuming Nie
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Abstract
Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a metallic gold surface-enhanced Raman scattering nanoparticle, a Raman reporter and a protection structure. The protection structure may include a thiol-polyethylene glycol to which may be attached a target-specific probe.
Claims18
A surface-enhanced Raman spectroscopic active composite nanostructure comprising:
- a single-core metallic nanoparticle with a diameter of 100 nm or less;
- a Raman reporter molecule disposed on the surface of the core;
- and
- an encapsulating protective layer disposed on the surface of the core and the reporter molecule, wherein the encapsulating protective layer is a thiolpolyethylene glycol, and wherein the encapsulated reporter molecule has a measurable surface-enhanced Raman spectroscopic signature.
1 more element
A surface-enhanced Raman spectroscopic active composite nanostructure comprising:
- a single-core metallic nanoparticle with a diameter of 100 nm or less;
- a Raman reporter molecule without an isothiocyanate group disposed on the surface of the core;
- and
- an encapsulating protective layer disposed on the surface of the core and the reporter molecule, wherein the encapsulating protective layer is a thiolpolyethylene glycol, and wherein the encapsulated reporter molecule has a measurable surface-enhanced Raman spectroscopic signature.
1 more element
Dependencies are inferred from the claim text.