Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
AssigneeSequoia Sciences, Inc.
InventorsGary Eldridge, Steven M Martin
Life of this patent
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Abstract
This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.
Claims18
A vaccine composition comprising (i) an effective amount of FimCH or truncated FimH, and (ii) an effective amount of phosphorylated hexaacyl disaccharide or pharmaceutically acceptable salts thereof.
A method for preparing a vaccine comprising the steps of:
- providing an adjuvant formulation comprising phosphorylated hexaacyl disaccharide or pharmaceutically acceptable salts thereof;
- and combining the adjuvant formulation with an effective amount of an antigen of FimCH or truncated FimH.
Dependencies are inferred from the claim text.