Dental gel composition of papain for the atraumatic treatment of caries and method of preparing same
AssigneeBrix USA, LLC
InventorMauricio Dobboletta
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Abstract
A papain dental gel composition is disclosed for the atraumatic treatment of caries which comprises papain with a final activity of at least 3,000 U/mg, wherein the papain is bio-encapsulated in a mixture of pH=7 buffer-C3-6 polyol-pectin-C2-6 alkanolamine-nonionic emulsifier, together with pharmaceutically acceptable coloring agents, preservatives and solvents. A method of preparing said papain composition is also disclosed.
Claims24
A dental composition of papain in the form of a gel for the atraumatic treatment of caries comprising papain with a final activity of at least 3,000 U/mg, wherein the papain is bio-encapsulated in a mixture comprising all of the following ingredients:
- pH=7 buffer,
- a C3-6 polyol,
- pectin,
- C2-6 alkanolamine,
- a nonionic emulsifier,
- optionally a pharmaceutically acceptable coloring agent
- a preservative, and
- a solvent,
- wherein the composition does not include chloramine.
A dental composition of papain in the form of a gel for the atraumatic treatment of caries, said composition comprising papain 10.00% w/w, citrus pectin 8.00% w/w, propyleneglycol 8.00% w/w, triethanolamine 0.72% w/w, polyoxyethylene-20 sorbitan monooleate 0.50% w/w, KH2PO4 0.0378% w/w, Na2HPO4 0.1283%, toluidine blue (1% w/w aq. sol.) 0.09% w/w, methylparaben 0.10% w/w, propylparaben 0.05% w/w, and distilled water 72.37% w/w,
- wherein the composition has a final activity of papain of at least 3000 U/mq, and
- wherein the composition does not include chloramine.
Dependencies are inferred from the claim text.