Pre-treatment agent and pre-treatment method for antithrombin III to be subjected to limulus test
AssigneeSeikagaku Corporation
InventorsMaki Aizawa, Toshio Oda, Jun Aketagawa
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Abstract
To provide means for reducing reaction interference observed when AT III is subjected to limulus test, whereby the limulus test of antithrombin III can be carried out at high accuracy. Reaction interference observed when AT III is subjected to limulus test can be reduced by subjecting AT III to a protein inactivation treatment in the co-presence of a divalent metal salt.
Claims6
A pre-treatment method for antithrombin III to be subjected to limulus test, the method comprising subjecting antithrombin III to a protein inactivation treatment, wherein the protein inactivation treatment is conducted in the co-presence of the pre-treatment agent which contains a divalent metal salt and wherein the protein inactivation treatment is not an alkali treatment,
- wherein antithrombin III is an injection pharmaceutical preparation of antithrombin III, and
- wherein a target substance of the limulus test is endotoxin.
Dependencies are inferred from the claim text.