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US 10,131,691 B2Granted
Compositions and methods for specific regulation of pyruvate dehydrogenase kinase
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDaria Mochly-Rosen, Nir Qvit, Marie-Helene Disatnik Dziesietnik
Life of this patent
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Abstract
A peptide composition is provided which specifically inhibits the ability of δ-protein kinase C (δPKC) to phosphorylate pyruvate dehydrogenase kinase (PDK) under ischemic conditions. The peptide composition is useful for treating or reducing tissue damage resulting from ischemia and/or reperfusion.
Claims5
A therapeutic peptide having a sequence selected from SEQ ID NO:
- 41 and SEQ ID NO:
- 42.
Dependencies are inferred from the claim text.