Back to results
US 10,131,626 B2Granted
3-aryl propiolonitrile compounds for thiol labeling
AssigneesUniversite De Strasbourg, Centre National De La Recherche Scientifique
InventorsAlain Wagner, Oleksandr Koniev
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.
Claims2
A process for the conjugation of a protein comprising at least one cysteine residue having a thiol moiety, the process comprising contacting the protein with a compound of formula (I):
- wherein each of R1, R2, R4 and R5 is hydrogen, and
- wherein R3 is selected from the group consisting of an antibody, a drug and a fluorescent probe bonded to the phenyl ring of the compound of formula (I), optionally through a linker group.
Dependencies are inferred from the claim text.