TCO conjugates and methods for delivery of therapeutic agents
AssigneesThe Regents of the University of California, The Research Foundation for The State University of New York
InventorsJose Manuel Mejia Oneto, Maksim Royzen
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Abstract
The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
Claims19
A method for selectively delivering an effective amount of a therapeutic or diagnostic agent to a first location of a targeted organ or tissue in a patient, comprising the steps of:
- (a) administering to the patient at the first location of the targeted organ or tissue a support composition comprising a biocompatible support and a first binding agent linked to the biocompatible support via a first linker, wherein the biocompatible support comprises at least one of a hydrogel, a polymer matrix, a metal, a ceramic, or a plastic, and the first binding agent comprises trans-cyclooctene or tetrazine;
- (b) administering to the patient a bioactive composition comprising a therapeutic or diagnostic agent, a second binding agent comprising trans-cyclooctene or tetrazine complementary to the first binding agent, and a releasable linker linking the therapeutic or diagnostic agent and the second binding agent, such that the first and second binding agent bind to one another upon contact;
- and
- (c) releasing the therapeutic or diagnostic agent, thereby delivering the therapeutic or diagnostic agent to the first location of the targeted organ or tissue.
Dependencies are inferred from the claim text.