Back to results
US 10,130,711 B2Granted
Chemical structures for localized delivery of therapeutic agents
AssigneesThe Regents of the University of California, Alchemical Research Holdings, LLC
InventorsJose Manuel Mejia Oneto, Ziyad F. Al-Rashid
Life of this patent
Estimating the term…
Abstract
The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
Claims9
A composition comprising:
- an implantable biocompatible solid support selected from the group consisting of polysaccharide hydrogels, alginate, cellulose, hyaluronic acid, chitosan, chitin, chondroitin sulfate, heparin, a polymer matrix, a metal, a ceramic and a plastic;
- at least one binding agent linked to the biocompatible solid support, wherein the at least one binding agent is capable of a bioorthogonal reaction with a corresponding binding agent and the bioorthogonal reaction is between a trans-cyclooctene and a tetrazine;
- and
- a linker covalently linking each binding agent to the implantable biocompatible solid support.
1 more element
Dependencies are inferred from the claim text.