Inhibition of histone methyltransferase for cardiac reprogramming
AssigneeDuke University
InventorsVictor J. Dzau, Maria Mirotsou
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Abstract
A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
Claims21
A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising contacting said non-cardiomyocytic cell or tissue with a composition comprising an inhibitor of histone methyltransferase activity or expression, and one or more of mir-1, mir-133, mir-208, and mir-499, wherein said non-cardiomyocytic cell is directly reprogrammed into cardiomyocytic tissue without a stem cell intermediary state.
Dependencies are inferred from the claim text.