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US 10,130,625 B2Granted
Linked diaryl compounds with anticancer properties and methods of using the same
AssigneesUniversity of Maryland, College Park, University of Maryland, Baltimore
InventorsHerman O. Sintim, Jie Zhou, Changhao Wang, Rena Lapidus
Life of this patent
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Abstract
Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. The method comprises administering an effective amount of a compound described herein to an individual in need thereof.
Claims11
A compound having the following formula:
- wherein
- W is selected from the group consisting of —R1, —OR1, —N(R1)2, —NO2, -halogen,
- wherein
- E is selected from the group consisting of oxygen atom, sulfur atom, —N(R1)—, and —N(OR1)—;
- X is —N—, or —C(R1)—;
- Y is selected from the group consisting of —R1, -ER1, —X(R1)2, and -halogen;
- n is 0-6;
- and
- R1 is selected from the group consisting of H, substituted or unsubstituted C1-C14 alkyl, substituted or unsubstituted C1-C14 heteroalkyl, wherein 1-7 of the chain atoms are independently O, N, S, P, or B, substituted or unsubstituted C1-C14 alkenyl, substituted or unsubstituted C1-C14 heteroalkenyl, wherein 1-7 of the chain atoms are independently O, N, S, P, or B, substituted or unsubstituted C1-C14 alkynyl, substituted or unsubstituted C1-C14 heteroalkynyl, wherein 1-7 of the chain atoms are independently O, N, S, P, or B, substituted or unsubstituted C5-C14 aryl, halo, heteroaryl having 5-14 ring atoms, wherein1-8 of the ring atoms are independently O, N, S, P, or B,
- wherein
- Y1 is selected from the group consisting of —OR1, —NR1, —SR1, and —R1;
- L is selected from the group consisting of direct bond, —O—, —NH—, —O—(CH2)m—O—, —NH—(CH2)m—NH—,
- wherein
- m is 2-6;
- Q is selected from the group consisting of —OH, —SH, —NR1,
- wherein
- A is selected from the group consisting of direct covalent bond, —SO2—NH—, —NH—;
- and
- Z is selected from the group consisting of —S—, —O—, -ER1—, —CH, —N—, —NH—, —N+(R1)—, and —N(R1)—.
16 more elements
Dependencies are inferred from the claim text.