Methods and compounds for increasing threonyl-tRNA synthetase activity
AssigneeUniversity of Vermont and State Agricultural College
InventorsChristopher Francklyn, Karen M. Lounsbury, Jason Botten
Life of this patent
Estimating the term…
Abstract
The invention includes, in part, methods and compounds for treating diseases and conditions characterized by reduced threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is reduced as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by reduced TARS activity.
Claims17
A method of increasing angiogenesis in at least one cell, the method comprising, contacting a plurality of cells with a pharmaceutical composition comprising an effective amount of a TARS-activity-enhancing compound to increase angiogenesis at least one cell of the plurality of cells, wherein the TARS-activity-enhancing compound comprises:
- (a) a threonyl-tRNA synthetase (TARS) nucleic acid molecule having the sequence of:
- (i) SEQ ID NO:
- 1, (ii) a modified SEQ ID NO:
- 1 that has at least 99% sequence identity to SEQ ID NO:
- 1, wherein each of (i) and (ii) encodes a TARS-activity-enhancing polypeptide;
- or
- (b) a TARS polypeptide having the sequence of (iv) SEQ ID NO:
- 2, (v) a modified SEQ ID NO:
- 2 that has at least 99% sequence identity to SEQ ID NO:
- 2, wherein each of (iv) and (v), is a TARS activity enhancing polypeptide.
The pharmaceutical composition for increasing angiogenesis comprising a TARS-activity-enhancing compound and a pharmaceutically acceptable carrier wherein the TARS-activity-enhancing compound comprises:
- (i) SEQ ID NO:
- 1, (ii) a modified SEQ ID NO:
- 1 that has at least 99% sequence identity to SEQ ID NO:
- 1 (iii) SEQ ID NO:2, or (iv) a modified SEQ ID NO:
- 2 that has at least 99% sequence identity to SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.