Method for producing stabilized amorphous calcium carbonate
AssigneeAmorphical Ltd.
InventorsOren Meiron, Binyamin Ashkenazi
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Abstract
Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.
Claims13
A suspension of a stabilized amorphous calcium carbonate (ACC) prepared by a method, the method comprising:
- combining an aqueous solution including a soluble calcium salt and a first stabilizer with an aqueous solution comprising a soluble carbonate so as to form an ACC suspension;
- and
- adding a water miscible organic solvent and a solution including a second stabilizer, substantially simultaneously or sequentially in any order, thereby obtaining a stabilized suspension of ACC;
- wherein the first stabilizer and the second stabilizer are the same or different;
- wherein a total amount of the first and second stabilizers constitutes up to about 12 weight % (wt %) of the suspension;
- and
- wherein the suspension of ACC includes at least about 5 wt % of the water miscible organic solvent.
A powder of stable amorphous calcium carbonate (ACC) prepared by a method, the method comprising:
- combining an aqueous solution including a soluble calcium salt and a first stabilizer with an aqueous solution comprising a soluble carbonate so as to form an ACC suspension;
- adding a water miscible organic solvent and a solution including a second stabilizer, substantially simultaneously or sequentially in any order, thereby obtaining a stabilized suspension of ACC;
- and
- separating ACC from said suspension of stabilized ACC and drying, thereby obtaining a powder of stable ACC;
- wherein the first stabilizer and the second stabilizer are the same or different and said powder includes between about 75 weight % (wt %) and about 88 wt % CaCO3, less than about 10 wt % water, and a phosphorylated organic acid or about 1 wt % to about 5 wt % of a non-phosphorylated hydroxyl-bearing amino acid.
A suspension of a stabilized amorphous calcium carbonate (ACC), the stabilized suspension comprising:
- an aqueous solution including:
- a soluble calcium salt;
- and
- a first stabilizer with an aqueous solution comprising a soluble carbonate;
- at least about 5 weight % (wt %) of a water miscible organic solvent;
- and
- a solution including a second stabilizer;
- wherein the first stabilizer and the second stabilizer are the same or different;
- wherein a total amount of the first and second stabilizers constitutes up to about 12 wt % of the suspension.
Dependencies are inferred from the claim text.