Secretagogues derived from oxalobacter formigenes
AssigneeOxthera Intellectual Property AB
InventorsElisabeth Lindner, Helena Cowley, Aaron Cowley, Maria Akerman
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Abstract
The present invention relates to a secretagogue compound derived from oxalate degrading bacteria, for use in the treatment of an oxalate related disease and/or oxalate related imbalance in a subject, wherein the administration of the secretagogue results in a reduction of urinary oxalate and/or plasma oxalate in the subject. The invention further relates to a pharmaceutical composition comprising such a secretagogue compound, a method for treating a subject suffering from an oxalate related disease, and to a method for preparing a secretagogue.
Claims10
A method for reducing oxalate in a subject in need thereof, comprising administering to the subject an effective amount of an isolated oxalate-degrading bacteria secretagogue having the amino acid sequence of any one of SEQ ID NOs. 3, 4, 6, 13 and 19, wherein the secretagogue is an Oxalobacter formigenes secretagogue, wherein the secretagogue promotes secretion of oxalate, and wherein administration of the secretagogue results in a reduction of urinary and/or plasma oxalate in the subject.
Dependencies are inferred from the claim text.