HIV-1 V3 mimotopes capable of inducing cross-clade neutralizing antibodies
AssigneeTexas Biomedical Research Institute
InventorsRuth M. Ruprecht, Michael Humbert
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Abstract
The invention provides methods, compositions and kits for treating and or preventing an HIV infection. For example, HIV envelope-like polypeptides (wild-type HIV polypeptides and mimotopes) may be administered to an individual so as to induce a protective immune response to HIV. Alternatively, antibodies directed to the HIV envelope-like polypeptides may be administered to an individual to treat or prevent an HIV infection and/or one or more symptoms associated with the infection (e.g., AIDS).
Claims16
An isolated HIV envelope-like polypeptide, wherein said polypeptide comprises a mimotope of a HIV envelope C-terminal region and an amino acid sequence of SEQ ID:
- 35.
Dependencies are inferred from the claim text.