Method for coupling a first compound to a second compound
AssigneeDow Global Technologies LLC
InventorsPatrick S. Hanley, Jossian Oppenheimer, Matthias S. Ober, William J. Kruper, Jr., Arkady L. Krasovskiy
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Abstract
The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an alkene; and reacting the first compound and the second compound in a reaction mixture, the reaction mixture including a catalyst having at least one group 10 atom, the reaction mixture under conditions effective to couple the first compound to the second compound.
Claims20
A method of coupling a first compound A1 to a second compound A2, the method comprising:
- providing the first compound A1 comprising an aryl group having a fluorosulfonate substituent of the formula —OSO2F or heteroaryl group having a fluorosulfonate substituent of the formula —OSO2F;
- providing the second compound A2:
- wherein each R substituent is independently Hydrogen, an aryl group, a heteroaryl group, an alkyl group, a cycloalkyl group, a nitro group, a halide, a nitrogen, a cyano group, a carboxyester group, an acetoxy group, a substituted alkyl, aryl, heteroaryl or cycloalkyl group, or any two of the R groups are constituent parts of a ring system;
- and
- reacting the first compound A1 and the second compound A2 in a reaction mixture, the reaction mixture including a catalyst having at least one group 10 atom, the reaction mixture under conditions effective to couple the first compound A1 to the second compound A2.
A method for coupling a first compound A1 to a second compound A2, as illustrated in Equation 1, comprising :
- providing sulfuryl fluoride, a base and the first compound A1 comprising an aryl having a hydroxyl substituent or a heteroaryl group having a hydroxyl substituent to a reaction mixture, the first compound comprising an aryl or a heteroaryl group;
- providing a catalyst having at least one group 10 atom and the second compound A2 to the reaction mixture:
- wherein each R substituent is independently Hydrogen, an aryl group, a heteroaryl group, an alkyl group, a cycloalkyl group, a nitro group, a halide, a nitrogen, a cyano group, a carboxyester group, an acetoxy group, a substituted alkyl, aryl, heteroaryl or cycloalkyl group, or any two of the R groups are constituent parts of a ring system;
- and
- allowing the reaction mixture to react under conditions to produce the product shown in Equation 1.
Dependencies are inferred from the claim text.