Alkylated influenza vaccines
AssigneeSanofi Pasteur Limited
InventorsBrooke S. Milner, Jonathan Haines, Steven L. Hauser, Janet Beebe Poli
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Abstract
The present invention provides, among other things, improved influenza vaccines based on hemagglutinins containing one or more alkylated cysteine residues. In particular, the present invention provides influenza vaccines containing hemagglutinins treated with an alkylating agent and methods of making the same. Inventive influenza vaccines provided by the present invention have a remarkable ability to retain potency as determined by Single Radial Immunodiffusion (SRID) assay upon storage.
Claims13
An influenza vaccine comprising a hemagglutinin treated with an alkylating agent, wherein the influenza vaccine is substantially free of alkylating agent and retains at least about 90% potency as determined by Single Radial Immunodiffusion (SRID) assay upon storage of about 6 months at a temperature ranging from 1-30° C.
Dependencies are inferred from the claim text.