# US 10,120,005 B2 · Synchronous detection circuit and method for determining a bio-impedance of a biological tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,120,005 B2 - Document ID: US10120005B2 - Status: Granted - Kind: B2 - Application number: 15/258,461 - Filed: 2016-09-07 - Published: 2018-03-08 - Granted: 2018-11-06 - Earliest claimed: 2016-09-07 - Assignees: Silicon Laboratories Inc. - Applicants: Silicon Laboratories Inc. - Inventors: Alexander Cherkassky; Bruce P. Del Signore - Web page: https://patentgrep.com/patent/US10120005B2 ## CPC - G01R 27/00: Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom - A61B 5/053: Measuring electrical impedance or conductance of a portion of the body - A61B 5/7225: {Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation (input circuits for detecting, measuring, or recording bioelectric or biomagnetic signals A61B5/30; specific diagnostic methods using bioelectric or biomagnetic signals A61B5/316)} - A61B 5/7278: {Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals} - G01N 27/04: by investigating resistance - G01R 19/0038: {Circuits for comparing several input signals and for indicating the result of this comparison, e.g. equal, different, greater, smaller (comparing pulses or pulse trains according to amplitude)} - G01R 25/005: {Circuits for comparing several input signals and for indicating the result of this comparison, e.g. equal, different, greater, smaller, or for passing one of the input signals as output signal} - A61B 5/0002: {Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network (endoradiosondes A61B5/07)} - A61B 5/024: Measuring pulse rate or heart rate - A61B 5/0537: Measuring body composition by impedance, e.g. tissue hydration or fat content - A61B 5/0816: {Measuring devices for examining respiratory frequency (measuring frequency of electric signals G01R23/00)} - G01R 27/02: Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant (by measuring phase angle only G01R25/00) - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract Embodiments of synchronous detection circuits and methods are provided for extracting magnitude and phase information from a waveform. One embodiment of a synchronous detection circuit includes a driver circuit, an analog-to-digital converter (ADC) and a controller. The driver circuit is configured to supply an input waveform at an input frequency to a load. The ADC is coupled to receive an output waveform from the load, and configured for generating four digital samples, each spaced 90° apart, for every period of the output waveform. The controller is configured for setting an oversampling rate (OSR) of the ADC, so that the ADC generates an integer number, M, of sub-samples for each digital sample generated by the ADC, where the integer number, M, of sub-samples is inversely proportional to the input frequency of the input waveform. The controller is further configured to use the digital samples generated by the ADC to extract magnitude and phase information from the output waveform. ## Claims ### Claim 1 A synchronous detection circuit configured to determine a bio-impedance of a biological tissue, the synchronous detection circuit comprising: a driver circuit configured to be coupled to the biological tissue, the driver circuit supplying an alternating current signal at an input frequency to a first pair of electrodes in contact with the biological tissue; an analog-to-digital converter (ADC) configured to be coupled to the biological tissue, the ADC receiving a voltage waveform from a second pair of electrodes in contact with the biological tissue, wherein each period of the voltage waveform comprises four quadrants, and wherein the ADC is configured for generating four digital samples per period of the voltage waveform, such that one digital sample is generated within each of the four quadrants; and a controller coupled to the ADC, the controller configured for: setting an oversampling rate (OSR) of the ADC, so that the ADC generates an integer number, M, of sub-samples during each quadrant of the voltage waveform, wherein the integer number, M, of sub-samples is inversely proportional to the input frequency of the alternating current signal; and determining the bio-impedance of the biological tissue by using the digital samples generated by the ADC to determine a magnitude and a phase of the voltage waveform. ### Claim 2 (depends on 1) The synchronous detection circuit as recited in claim 1, wherein the controller is configured for using the four digital samples generated per period of the voltage waveform to calculate new magnitude and phase values every period of the voltage waveform. ### Claim 3 (depends on 1) The synchronous detection circuit as recited in claim 1, wherein the controller is configured for: averaging the four digital samples generated over a number, P, of periods of the voltage waveform; and using the averaged digital samples to calculate new magnitude and phase values every P periods of the voltage waveform. ### Claim 4 (depends on 1) The synchronous detection circuit as recited in claim 1, wherein the controller is further configured for setting a decimating rate (DR) of the ADC equal to the oversampling rate (OSR) of the ADC, so that the ADC generates one digital sample for every M number of sub-samples. ### Claim 5 (depends on 4) The synchronous detection circuit as recited in claim 4, wherein the ADC is configured for generating the digital samples and the sub-samples in synchronization with a clock signal having a fixed clock frequency, and wherein the integer number, M, of sub-samples is proportional to the fixed clock frequency and inversely proportional to the input frequency of the alternating current signal. ### Claim 6 (depends on 5) The synchronous detection circuit as recited in claim 5, wherein the integer number, M, of sub-samples is substantially equal to the fixed clock frequency divided by 4N times the input frequency, where N is an integer number greater than or equal to 1. ### Claim 7 (depends on 4) The synchronous detection circuit as recited in claim 4, wherein the controller is configured for setting the OSR and the DR of the ADC equal to an integer multiple of the integer number, M, wherein the input frequency of the alternating current signal is programmable and selected by the controller from a range of input frequencies, and wherein the integer multiple changes with changes in input frequency. ### Claim 8 (depends on 7) The synchronous detection circuit as recited in claim 7, wherein the controller is configured for setting the OSR and the DR of the ADC equal to N times M for input frequencies of 20 kHz and above, where N is an integer number greater than or equal to 1. ### Claim 9 (depends on 7) The synchronous detection circuit as recited in claim 7, wherein the controller is configured for setting the OSR of the ADC equal to N times M divided by X for input frequencies below 20 kHz, where X is an integer number greater than or equal to 2. ### Claim 10 (depends on 7) The synchronous detection circuit as recited in claim 7, further comprising a memory component configured for storing a table of values comprising predetermined values of M, N and OSR for each input frequency within the range of input frequencies, and wherein the controller is configured for using the table of values to set the OSR and the DR of the ADC. ### Claim 11 (depends on 1) The synchronous detection circuit as recited in claim 1, further comprising a waveform generator coupled to the driver circuit, the waveform generator configured for generating a sinusoidal waveform at a programmable input frequency and phase, and coupled to the driver circuit for supplying the sinusoidal waveform to the driver circuit for generating the alternating current signal. ### Claim 12 (depends on 11) The synchronous detection circuit as recited in claim 11, wherein the waveform generator is further coupled for supplying a digital signal to the driver circuit for controlling an amplitude of the alternating current signal. ### Claim 13 (depends on 12) The synchronous detection circuit as recited in claim 12, wherein the driver circuit comprises a current-controlled, digital-to-analog converter (I-DAC) having a number of programmable current amplitudes selectable by the digital signal. ### Claim 14 (depends on 1) The synchronous detection circuit as recited in claim 1, further comprising a common mode voltage (CMV) feedback circuit coupled for sensing a CMV between the first pair of electrodes, and further coupled to the driver circuit for setting the CMV equal to a desired voltage. ### Claim 15 A method for determining a bio-impedance of a biological tissue, the method comprising: supplying an alternating current signal at an input frequency to a first pair of electrodes in contact with the biological tissue; receiving a voltage waveform from a second pair of electrodes in contact with the biological tissue, wherein the voltage waveform comprises four quadrants for each period of the voltage waveform; oversampling the voltage waveform so as to generate an integer number, M, of sub-samples for each quadrant of the voltage waveform, wherein the integer number, M, is inversely proportional to the input frequency of the alternating current signal; decimating the integer number, M, of sub-samples so as to generate four digital samples per period of the voltage waveform, such that one digital sample is generated within each quadrant; and using the digital samples to extract magnitude and phase values from the voltage waveform to determine the bio-impedance of the biological tissue. ### Claim 16 (depends on 15) The method as recited in claim 15, wherein prior to the step of supplying an alternating current signal, the method further comprises selecting the input frequency from a range of available input frequencies comprising about 1 kHz to about 100 kHz. ### Claim 17 (depends on 16) The method as recited in claim 16, wherein prior to the steps of oversampling and decimating, the method further comprises setting an oversampling rate (OSR) of an analog-to-digital converter (ADC) equal to a decimating rate (DR) of the ADC, so that the ADC generates the integer number, M, of sub-samples and the one digital sample for each quadrant of the voltage waveform. ### Claim 18 (depends on 17) The method as recited in claim 17, wherein the step of the setting the OSR and the DR of the ADC comprises setting the OSR and the DR equal to an integer multiple of the integer number, M, and wherein the integer multiple depends on the input frequency selected from the range of available input frequencies. ### Claim 19 (depends on 17) The method as recited in claim 17, wherein the step of the setting the OSR and the DR of the ADC comprises setting the OSR and the DR equal to N times M for input frequencies of 20 kHz and above, where N is an integer number greater than or equal to 1. ### Claim 20 (depends on 17) The method as recited in claim 17, wherein the step of the setting the OSR and the DR of the ADC comprises setting the OSR equal to N times M divided by X, where X is an integer number greater than or equal to 2, and setting the DR equal to N times M, for input frequencies below 20 kHz. ### Claim 21 (depends on 15) The method as recited in claim 15, wherein the step of using the digital samples comprises using the four digital samples generated per period of the voltage waveform to calculate new magnitude and phase values every period of the voltage waveform. ### Claim 22 (depends on 15) The method as recited in claim 15, wherein the step of using the digital samples comprises: averaging the four digital samples generated over a number, P, of periods of the voltage waveform; and using the averaged digital samples to calculate new magnitude and phase values every P periods of the voltage waveform.