# US 10,119,983 B2 · Sample manipulation device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,119,983 B2 - Document ID: US10119983B2 - Status: Granted - Kind: B2 - Application number: 15/104,152 - Filed: 2014-12-05 - Published: 2016-11-03 - Granted: 2018-11-06 - Earliest claimed: 2013-12-13 - Assignees: Hamilton Bonaduz AG - Applicants: Hamilton Bonaduz AG - Inventors: Peter Hoffmann; Martin Frey; Beat Zahner; Petra Tappe - Web page: https://patentgrep.com/patent/US10119983B2 ## CPC - G01N 35/04: Details of the conveyor system {(G01N35/021 - G01N35/028 take precedence)} - B01L 3/50825: {Closing or opening means, corks, bungs} - G01N 35/00732: {Identification of carriers, materials or components in automatic analysers} - G01N 35/028: {having reaction cells in the form of microtitration plates} - B01L 9/523: {for multisample carriers, e.g. used for microtitration plates} - G01N 2035/00801: {Holders for sample carriers, e.g. trays, caroussel, racks} - G01N 2035/0405: {manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE ## Abstract Described herein are sample manipulation devices, for removing lids from and/or for placing lids onto sample containers. Such devices include a sample unit including a sample carrier receptacle for receiving at least one sample carrier for holding one or more sample containers, and a manipulation unit having at least one manipulation tool, where the sample unit and the manipulation unit are movable relative to each other along a movement direction. The sample unit is also movable between a first orientation in which a longitudinal direction of a sample carrier in the sample carrier receptacle is parallel to the movement direction between sample unit and manipulation unit, and a second orientation in which a transverse direction, which is orthogonal to the longitudinal direction, of a sample carrier in the sample carrier receptacle is parallel to the movement direction between sample unit and manipulation unit. ## Claims ### Claim 1 A sample manipulation device for removing lids from sample containers and placing lids onto sample containers, the sample manipulation device comprising: a sample unit; and a manipulation unit having at least one manipulation tool configured to remove and place a lid on a sample container, and configured to rotate to threadedly engage and threadedly disengage the lid from the sample container; wherein the sample unit and the manipulation unit are movable relative to each other along a movement direction; wherein the sample unit comprises a sample carrier receptacle configured to receive a sample carrier for holding one or more sample containers, said sample carrier extending in a longitudinal direction and a transverse direction orthogonal to said longitudinal direction, a dimension of the sample carrier being larger in the longitudinal direction than in the transverse direction; wherein the sample unit is transferable between a first orientation in which the longitudinal direction of the sample carrier received in the sample carrier receptacle is parallel to the movement direction between the sample unit and the manipulation unit, and a second orientation in which the transverse direction of the sample carrier received in the sample carrier receptacle is parallel to the movement direction between the sample unit and the manipulation unit; wherein the sample unit further comprises a sample carriage that is displaceable in the movement direction, and wherein the sample carrier receptacle is rotatably supported in the sample carriage; and wherein the sample carriage comprises a sample lid carrier receptacle in which a sample lid carrier associated with and having a configuration corresponding to the sample carrier can be received, the sample lid carrier configured to receive the lid removed from the sample container, wherein the sample lid carrier receptacle is formed such that, both in the first orientation of the sample unit and in the second orientation of the sample unit, the respectively associated sample lid carrier can be received in the same orientation in relation to the sample carrier received in the sample carrier receptacle. ### Claim 2 (depends on 1) The sample manipulation device according to claim 1, wherein the sample carrier has a first axis of symmetry extending in the longitudinal direction and a second axis of symmetry extending in the transverse direction and orthogonal to the first axis of symmetry. ### Claim 3 (depends on 1) The sample manipulation device according to claim 1, wherein, for transfer between the first orientation and the second orientation, the sample carrier receptacle is rotatable about an axis of rotation orthogonal to a plane defined by the longitudinal direction and the transverse direction. ### Claim 4 (depends on 3) The sample manipulation device according to claim 3, wherein the axis of rotation is a vertical axis and arranged centrally with respect to the sample carrier received in the sample carrier receptacle. ### Claim 5 (depends on 1) The sample manipulation device according to claim 1, further comprising a rotary drive acting on the sample carrier received in the sample carrier receptacle for rotation thereof at least between said first and second orientations. ### Claim 6 (depends on 5) The sample manipulation device according to claim 5, wherein the sample carrier receptacle is coupled with a sample table that is rotatable about a vertical axis, wherein the sample carrier receptacle is formed in the sample table. ### Claim 7 (depends on 6) The sample manipulation device according to claim 6, wherein the sample table is acted upon by the rotary drive, wherein the sample table has at least one circular peripheral surface for cooperation with the rotary drive. ### Claim 8 (depends on 7) The sample manipulation device according to claim 7, wherein the at least one circular peripheral surface of the sample table is formed with teeth cooperating with an output pinion of the rotary drive, or has a driving surface frictionally cooperating with an output wheel of the rotary drive. ### Claim 9 (depends on 1) The sample manipulation device according to claim 1, wherein the sample lid carrier receptacle in a plan view has an outline resulting from a combination of outlines of two sample carrier receptacles rotated relative to each other by an angle of 90 degrees about a common axis of rotation, wherein the sample lid carrier receptacle has a cross-shaped outline in a plan view. ### Claim 10 (depends on 1) The sample manipulation device according to claim 1, further comprising a linear drive acting on the sample unit and adapted to displace the sample unit in the movement direction in relation to the manipulation unit. ### Claim 11 (depends on 10) The sample manipulation device according to claim 10, wherein the linear drive is arranged underneath the sample unit and engages the sample carriage. ### Claim 12 (depends on 1) The sample manipulation device according to claim 1, wherein the at least one manipulation tool is attached to the manipulation unit so as to be rotatable about a vertical axis, and is displaceable in a vertical direction in order to move the at least one manipulation tool towards the sample unit. ### Claim 13 (depends on 12) The sample manipulation device according to claim 12, wherein the manipulation unit comprises a plurality of manipulation tools that are lined up in a direction orthogonal to a vertical plane defined by the movement direction of the manipulation unit. ### Claim 14 (depends on 1) The sample manipulation device according to claim 1, wherein the manipulation unit comprises an exchangeably mounted tool head, the tool head as a unit being displaceable in a vertical direction and the at least one manipulation tool being attached to the tool head so as to be rotatable about a vertical axis. ### Claim 15 (depends on 1) The sample manipulation device according to claim 1, further comprising a sample container identification device for identification of the sample carrier and an individual sample container located in the sample carrier. ### Claim 16 (depends on 15) The sample manipulation device according to claim 15, wherein the sample container identification device is formed such that it is capable of recognizing identification patterns located at the bottom of a respective sample container. ### Claim 17 (depends on 15) The sample manipulation device according to claim 15, wherein the sample container identification device comprises at least one optical sensor. ### Claim 18 (depends on 1) The sample manipulation device according to claim 1, wherein the manipulation unit has a plurality of manipulation tools, each configured to remove and place a lid on a respective sample container.