Back to results
US 10,119,966 B2Granted
Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and assay kit
AssigneeStichting voor de Technische Wetenschappen
InventorsWaltherus Jacobus Wilhelmus Van Venrooij, Jan Wouter Drijfhout, Martinus Adrianus Maria Van Boekel, Gerardus Jozef Maria Pruijn
Life of this patent
Estimating the term…
Abstract
Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.
Claims9
An isolated peptide comprising a sequence with the formula (III):
- (B1-B2-B3-B4-B5-B6)-Cit-(B7)-(B8-B9-B10-B11) (III)
- wherein Cit represents citrulline and
- B1-B2-B3-B4-B5-B6 is an amino acid sequence selected from:
- (SEQ ID NO:
- 53)
- INCitRAS
- (SEQ ID NO:
- 54)
- ICitKRLY
- (SEQ ID NO:
- 55)
- KCitCitYNI
- (SEQ ID NO:
- 56)
- RLYFICit
- (SEQ ID NO:
- 57)
- IRQGAR
- (SEQ ID NO:
- 58)
- CitERCitVQ
- (SEQ ID NO:
- 59)
- CitHQRIT
- (SEQ ID NO:
- 60)
- RICitRVCit
- (SEQ ID NO:
- 61)
- GRNQRY
- (SEQ ID NO:
- 62)
- RCitRQHP
- (SEQ ID NO:
- 63)
- CitCitRCitVA
- (SEQ ID NO:
- 64)
- RPKQHV
- (SEQ ID NO:
- 65)
- RKCitGCitR
- (SEQ ID NO:
- 66)
- RCitCitRNT
- (SEQ ID NO:
- 67)
- RCitQCitFT
- (SEQ ID NO:
- 68)
- QLVYLQ
- (SEQ ID NO:
- 69)
- QYNRFK
- (SEQ ID NO:
- 70)
- CitLRHIR
- (SEQ ID NO:
- 71)
- PRCitCitCitK
- (SEQ ID NO:
- 72)
- RCitQVRY
- (SEQ ID NO:
- 73)
- GRCitHAH
- (SEQ ID NO:
- 74)
- ARHVIR
- (SEQ ID NO:
- 75)
- RCitGHMF
- (SEQ ID NO:
- 76)
- GRNIRV
- (SEQ ID NO:
- 77)
- QIFYLCit
- (SEQ ID NO:
- 78)
- RQGPIA
- (SEQ ID NO:
- 79)
- GVYLVR
- (SEQ ID NO:
- 80)
- NCitCitRRV
- (SEQ ID NO:
- 81)
- KCitRLCitY
- (SEQ ID NO:
- 82)
- GRRCitCitL
- (SEQ ID NO:
- 83)
- RMPHCitH;
- and
- wherein B7 represents an amino acid other than glycine;
- B8-B9-B10-B11 represents an amino acid sequence selected from:
- (SEQ ID NO:
- 84)
- CitHRR
- (SEQ ID NO:
- 85)
- CitIRR
- (SEQ ID NO:
- 86)
- FRRN
- (SEQ ID NO:
- 87)
- AQTT
- (SEQ ID NO:
- 88)
- GYPK
- (SEQ ID NO:
- 89)
- RPPQ
- (SEQ ID NO:
- 90)
- GCitRK
- (SEQ ID NO:
- 91)
- PIPR
- (SEQ ID NO:
- 92)
- YTIH
- (SEQ ID NO:
- 93)
- RIKA
- (SEQ ID NO:
- 94)
- CitRVR
- (SEQ ID NO:
- 95)
- TRRP
- (SEQ ID NO:
- 96)
- TIRP
- (SEQ ID NO:
- 97)
- IKCitR
- (SEQ ID NO:
- 98)
- RNVV
- (SEQ ID NO:
- 99)
- CitRRY
- (SEQ ID NO:
- 100)
- CitRPR
- (SEQ ID NO:
- 101)
- TRCitCit
- (SEQ ID NO:
- 102)
- CitCitGR
- (SEQ ID NO:
- 103)
- LCitRCit
- (SEQ ID NO:
- 104)
- RVRCit
- (SEQ ID NO:
- 105)
- VPRT
- (SEQ ID NO:
- 106)
- YCitFR
- (SEQ ID NO:
- 107)
- ARCitCit
- (SEQ ID NO:
- 108)
- RQCitR
- (SEQ ID NO:
- 109)
- HIRR
- (SEQ ID NO:
- 110)
- CitMMR
- (SEQ ID NO:
- 111)
- CitRICit
- (SEQ ID NO:
- 112)
- VRKS
- (SEQ ID NO:
- 113)
- PCitCitR
- (SEQ ID NO:
- 114)
- CitRRK
189 more elements
Dependencies are inferred from the claim text.