# US 10,119,926 B2 · Analytical device and autosampler used in the same

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- Number: US 10,119,926 B2
- Document ID: US10119926B2
- Status: Granted
- Kind: B2
- Application number: 15/032,348
- Filed: 2013-12-02
- Published: 2016-09-01
- Granted: 2018-11-06
- Earliest claimed: 2013-12-02
- Assignees: Shimadzu Corporation
- Applicants: Shimadzu Corporation
- Inventors: Akira Aono
- Web page: https://patentgrep.com/patent/US10119926B2

## CPC

- G01N 25/20: by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity (calorimeters per se G01K)
- G01N 1/44: Sample treatment involving radiation, e.g. heat
- G01N 30/24: Automatic injection systems
- G01N 30/30: of temperature
- G01N 2030/3076: {using specially adapted T(t) profile}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A heat retention start timing of each sample container is determined based on a room temperature detected by a room temperature sensor, and a starting temperature and an ending temperature of each sample at a time of programmed temperature analysis that are stored in an analysis condition storage section. Since cooling speed of each sample container varies depending on the room temperature, the cooling time (A12, B12, C12, . . . ) of each sample container may be predicted based on the ending temperature of each sample at the time of programmed temperature analysis, the starting temperature of a next sample at the time of the programmed temperature analysis, and the room temperature. By determining the heat retention start timing of each sample container according to the cooling time (A12, B12, C12, . . . ) of each sample container predicted in the above manner, a margin time (A13, B13, C13, . . . ) after the cooling time may be prevented from becoming unnecessarily long. Accordingly, the processing performance may be improved compared to a conventional configuration where the heat retention start timings of sample containers are shifted by fixed time intervals.

## Claims

### Claim 1

An analytical device comprising:
an analytical section for performing programmed temperature analysis by heating a sample;
an autosampler for sequentially heating a plurality of sample containers containing samples each for a fixed period of heating time, and for sequentially introducing a sample into the analytical section starting from a sample container for which the fixed period of heating time has passed;
an analysis condition storage section for storing an analysis condition including a starting temperature and an ending temperature of each sample at a time of the programmed temperature analysis;
a room temperature sensor for detecting a room temperature of a room surrounding the analytical device; and
a heat retention start timing determination section for determining a heating start timing of each sample container based on the room temperature detected by the room temperature sensor, and the starting temperature and the ending temperature of each sample at a time of the programmed temperature analysis that are stored in the analysis condition storage section.

### Claim 2 (depends on 1)

The analytical device according to claim 1, further comprising a cooling time calculation section for calculating a cooling time after the programmed temperature analysis of each sample based on the room temperature detected by the room temperature sensor, and the starting temperature and the ending temperature of each sample at a time of the programmed temperature analysis that are stored in the analysis condition storage section,
wherein the heat retention start timing determination section determines the heating start timing of each sample container based on the cooling time after the programmed temperature analysis of each sample calculated by the cooling time calculation section.

### Claim 3 (depends on 2)

The analytical device according to claim 2, further comprising a cycle time calculation section for calculating a cycle time from a start timing of the programmed temperature analysis of each sample to a start timing of the programmed temperature analysis of a next sample based on the cooling time after the programmed temperature analysis of each sample calculated by the cooling time calculation section,
wherein the heat retention start timing determination section determines the heating start timing of each sample container based on the cycle time of each sample at a time of the programmed temperature analysis calculated by the cycle time calculation section.

### Claim 4

An autosampler for sequentially heating a plurality of sample containers containing samples for a fixed period of heating time, and for sequentially introducing a sample into an analytical section starting from a sample container for which the fixed period of heating time has passed, the autosampler comprising:
a heat retention start timing determination section for determining a heating start timing of each sample container based on a room temperature of a room surrounding the analytical device detected by a room temperature sensor, and a starting temperature and an ending temperature of each sample at a time of programmed temperature analysis.