# US 10,119,911 B2 · Fabrication of a fluorescent material for sensing an analyte

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- Number: US 10,119,911 B2
- Document ID: US10119911B2
- Status: Granted
- Kind: B2
- Application number: 15/606,260
- Filed: 2017-05-26
- Published: 2017-09-14
- Granted: 2018-11-06
- Earliest claimed: 2014-07-23
- Assignees: Senseonics, Incorporated
- Applicants: Senseonics, Incorporated
- Inventors: Philip Huffstetler; Jeremy Emken; Todd Whitehurst
- Web page: https://patentgrep.com/patent/US10119911B2

## CPC

- G01N 21/6428: {Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" (in vivo A61B5/00; immunoassay G01N33/53)}
- G01N 21/77: by observing the effect on a chemical indicator
- G01N 33/544: the carrier being organic
- G01N 33/582: {with fluorescent label}
- G01N 31/22: using chemical indicators (G01N31/02 takes precedence)
- G01N 2021/773: {Porous polymer jacket; Polymer matrix with indicator}
- G01N 2021/7786: {Fluorescence}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.

## Claims

### Claim 1

An analyte indicator comprising:
a porous base comprising nylon, cellulose, cellulose acetate, polypropylene, polyethylene, poly(ethylene terephthalate), poly(ether sulfone), poly(vinylidene difluoride), or poly(tetrafluoroethylene);
an indicator polymer chain attached onto or out of the porous base; and
indicator molecules attached to the indicator polymer chain.

### Claim 2 (depends on 1)

The analyte indicator of claim 1, wherein the analyte indicator retains its physical, chemical, and optical properties in the presence of compression.

### Claim 3 (depends on 1)

The analyte indicator of claim 1, wherein the porous base does not vary in opacity.

### Claim 4 (depends on 1)

The analyte indicator of claim 1, wherein the indicator polymer chain is hydrophilic or amphiphilic.

### Claim 5 (depends on 1)

The analyte indicator of claim 1, wherein the indicator polymer chain is a first indicator polymer chain, and the analyte indicator comprises:
a second indicator polymer chain attached or polymerized onto or out of the porous base; and
indicator molecules attached to the second indicator polymer chain.

### Claim 6 (depends on 5)

The analyte indicator of claim 5, wherein the first and second indicator polymer chains are hydrophilic or amphiphilic.

### Claim 7 (depends on 5)

The analyte indicator of claim 5, wherein the second indicator polymer chain is polymerized onto or out of the porous base.

### Claim 8

An analyte sensor comprising:
the analyte indicator including:
a porous base;
an indicator polymer chain attached onto or out of the porous base; and
indicator molecules attached to the indicator polymer chain; and
a porous membrane over the analyte indicator.

### Claim 9 (depends on 1)

The analyte indicator of claim 1, wherein the porous base is flexible.

### Claim 10 (depends on 8)

The analyte sensor of claim 8, wherein the base comprises nylon, cellulose, cellulose acetate, polypropylene, polyethylene, poly(ethylene terephthalate), poly(ether sulfone), poly(vinylidene difluoride), or poly(tetrafluoroethylene).

### Claim 11 (depends on 10)

The analyte sensor of claim 10, further comprising a layer of dark material wrapped over the porous membrane.

### Claim 12 (depends on 10)

The analyte sensor of claim 10, wherein the porous membrane comprises nylon, cellulose, cellulose acetate, polypropylene, polyethylene, poly(ethylene terephthalate), poly(ether sulfone), poly(vinylidene difluoride), or poly(tetrafluoroethylene).

### Claim 13 (depends on 1)

An analyte sensor comprising:
the analyte indicator of claim 1,
a light source configured to emit excitation light to the analyte indicator; and
a photodetector configured to receive fluorescent light emitted by the analyte indicator.

### Claim 14 (depends on 1)

The analyte indicator of claim 1, wherein the indicator polymer chain is polymerized onto or out of the porous base.

### Claim 15 (depends on 8)

The analyte sensor of claim 8, wherein the analyte indicator retains its physical, chemical, and optical properties in the presence of compression.

### Claim 16 (depends on 8)

The analyte sensor of claim 8, wherein the porous base does not vary in opacity.

### Claim 17 (depends on 8)

The analyte sensor of claim 8, wherein the indicator polymer chain is hydrophilic or amphiphilic.

### Claim 18 (depends on 8)

The analyte sensor of claim 8, wherein the indicator polymer chain is a first indicator polymer chain, and the analyte indicator comprises:
a second indicator polymer chain attached or polymerized onto or out of the porous base; and
indicator molecules attached to the second indicator polymer chain.

### Claim 19 (depends on 18)

The analyte sensor of claim 18, wherein the first and second indicator polymer chains are hydrophilic or amphiphilic.

### Claim 20 (depends on 18)

The analyte sensor of claim 18, wherein the second indicator polymer chain is polymerized onto or out of the porous base.

### Claim 21 (depends on 8)

The analyte sensor of claim 8, wherein the porous base is flexible.

### Claim 22 (depends on 8)

The analyte sensor of claim 8, wherein the indicator polymer chain is polymerized onto or out of the porous base.