Bioreactor using oxygen-carrying molecules

A bioreactor comprising:

• at least one first chamber comprising cells in a culture medium and to provide growth conditions suitable for cell culturing;
• and
• a receptacle comprising:
• a second chamber for said bioreactor, at least partially defined by an oxygen-permeable membrane, and
• a plurality of oxygen-carrying molecules contained within said second chamber, said oxygen carrying molecules being chosen from extracellular hemoglobins isolated from worms belonging to Arenicolidae family or Nereididae family, said oxygen-carrying molecules being in a form selected from the group consisting of dissolved in a sterile buffer suitable for cell culture, dissolved in a medium used for cell culture, dissolved in a cell culture, lyophilized, and thawed,
• wherein said receptacle does not comprise any hollow fiber system, and
• wherein said receptacle is positioned within said first chamber.