# US 10,119,108 B2 · Manufacturing within a single-use container

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- Number: US 10,119,108 B2
- Document ID: US10119108B2
- Status: Granted
- Kind: B2
- Application number: 14/927,848
- Filed: 2015-10-30
- Published: 2016-03-10
- Granted: 2018-11-06
- Earliest claimed: 2013-08-01
- Assignees: Sartorius Stedim Biotech GmbH
- Applicants: Sartorius Stedim Biotech GmbH
- Inventors: Frank Maggiore
- Web page: https://patentgrep.com/patent/US10119108B2

## CPC

- B29C 64/112: using individual droplets, e.g. from jetting heads
- B25J 9/10: characterised by positioning means for manipulator elements
- B25J 9/14: fluid
- B25J 21/00: Chambers provided with manipulation devices (constructional features of the mounting of the manipulator in the wall B25J1/08 {; glove-boxes for nuclear applications G21F7/04})
- B29C 64/188: involving additional operations performed on the added layers, e.g. smoothing, grinding or thickness control (surface shaping B29C59/00; after-treatment of articles without altering their shape B29C71/00)
- B29C 64/209: Heads; Nozzles
- B29C 64/227: Driving means
- B29C 64/232: for motion along the axis orthogonal to the plane of a layer
- B29C 64/236: for motion in a direction within the plane of a layer
- B29C 64/255: Enclosures for the building material, e.g. powder containers
- B33Y 30/00: Apparatus for additive manufacturing; Details thereof or accessories therefor
- B33Y 40/00: Auxiliary operations or equipment, e.g. for material handling
- C12M 21/08: {for producing artificial tissue or for ex-vivo cultivation of tissue (prostheses A61F2/00, grafts A61L27/00)}
- C12M 25/00: {Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings}
- C12M 29/00: {Means for introduction, extraction or recirculation of materials, e.g. pumps (pumps per se F04B)}
- C12M 41/12: {of temperature (controlling the temperature of chemical or physical processes B01J19/0013, heating or cooling apparatus for laboratory use B01L7/00)}
- C12M 41/40: {of pressure}
- C12M 41/48: {Automatic or computerized control (automatic analysis G01N35/00)}
- B29C 64/205: Means for applying layers
- B29C 64/25: Housings, e.g. machine housings
- B29C 64/307: Handling of material to be used in additive manufacturing
- B29C 64/321: Feeding
- B29C 64/364: Conditioning of environment
- B29C 64/379: Handling of additively manufactured objects, e.g. using robots
- B29C 65/08: using ultrasonic vibrations {(non-plastics element to plastics elements B29C65/645)}
- B29C 66/0018: {being sterile}
- B29C 66/1122: {Single lap to lap joints, i.e. overlap joints (B29C66/45, B29C66/472, B29C66/52272 take precedence)}
- B29C 66/43: {Joining a relatively small portion of the surface of said articles (B29C66/45 takes precedence)}
- B29C 66/73921: {characterised by the materials of both parts being thermoplastics}
- B29C 66/8322: {Joining or pressing tools reciprocating along one axis}
- C12M 33/00: {Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus (chemical or physical laboratory apparatus in general B01L, devices for taking cell samples A61B10/0045, withdrawing or distributing predetermined quantities of fluid B01L99/00)}
- Y10S 901/19: Drive system for arm
- Y10S 901/22: Fluid motor
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- B25J: MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION DEVICES ({manipulators specially adapted for use in surgery A61B34/70; manipulators used in cleaning hollow articles B08B9/04}; manipulators associated with rolling mills B21B39/20; manipulators associated with forging machines B21J13/10; {manipulators associated with picking-up and placing mechanisms B23P19/007}; means for holding wheels or parts thereof B60B30/00; {vehicles with ground-engaging propulsion means, e.g. walking members B62D57/02, B62D57/032; devices for picking-up and depositing articles or materials between conveyors B65G47/90, B65G47/91; manipulators with gripping or holding means for transferring packages B65H67/065}; cranes B66C; {manipulators used in the protection or supervision of pipe-line installations F17D5/00; walking equipment adapted for nuclear steam-generators F22B37/006}; manipulators specially adapted for, or associated with, nuclear reactors G21C; {apparatus used for handling wafers during manufacture or treatment of semiconductor H10P72/50})
- B33Y: ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- C12M: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; {APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS}
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

A manufacturing assembly has at least a sterilizable chamber containing at least one of a three-dimensional printing device (additive manufacturing), a Computer Numerical Controlled (CNC) finishing head (subtractive manufacturing), a vacuum-forming unit, an injection-molding unit, a laser-cutting unit, a ultrasonic-welding unit, a robotic arman analysis device, a sampling device or a combination thereof. A plurality of individual sterilizable chambers may be aseptically connected into a network of sterilizable chambers that provides additional functionality for the manufacturing assembly. A sterilizable printer assembly may include at least one printing head, a printing platform, and a driving mechanism adapted to perform a movement of the at least one printing head relative to the printing platform along three degrees of freedom; a printer housing enclosing the printer assembly in a sterile manner, at least one aseptic connector fluidly connected to a corresponding one of the at least one printing head.

## Claims

### Claim 1

A printing system comprising:
a three dimensional printing device having:
a sterilizable printer assembly including:
a sterilizable chamber; and
a multiaxis printing assembly including:
at least one printing head;
a plurality of robotic components for positioning the at least one printing head of the multiaxis printing assembly into position over a fixed printing platform and for pushing and/or pulling at least one printing tray across the fixed printing platform along a plurality of tracks;
a drive mechanism configured to control movements of the robotic components; and
a central body configured to connect the at least one printing head and the robotic components.

### Claim 2 (depends on 1)

The printing system of claim 1, wherein:
the multiaxis printing assembly is a tethered multiaxis printing assembly;
the at least one printing head has a tubing line to a port in the sterilizable chamber for transferring at least one of a fluid and material inputs configured to be dispensed by the at least one printing head, and the three dimensional printing device further comprises an aseptic connector to connect at least one of an external fluid connection and an external material connection to the port in the sterilizable chamber;
the robotic components comprise soft robotic actuators for positioning the tethered multiaxis printing assembly into position over the fixed printing platform,
the drive mechanism is a fluid drive mechanism comprising at least one of an externally-driven hydraulic and pneumatic drive mechanism configured to control the movements of the soft robotic actuators; and
the central body is further configured to connect the at least one printing head and the soft robotic actuators to the tubing line and the fluid drive mechanism, respectively.

### Claim 3 (depends on 2)

The printing system of claim 2, wherein:
the soft robotic actuators are selectively curled and uncurled for positioning the printing head and the printing tray relative to one another.