# US 10,119,003 B2 · Surfactant-based monolithic columns, methods for making the same, and methods for using the same

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,119,003 B2
- Document ID: US10119003B2
- Status: Granted
- Kind: B2
- Application number: 13/886,921
- Filed: 2013-05-03
- Published: 2013-09-19
- Granted: 2018-11-06
- Earliest claimed: 2008-04-01
- Assignees: Georgia State University Research Foundation, Inc.
- Applicants: Georgia State University Research Foundation, Inc.
- Inventors: Shahab Ahmed Shamsi; Congying Gu; Jun He
- Web page: https://patentgrep.com/patent/US10119003B2

## CPC

- C08J 9/127: {Mixtures of organic and inorganic blowing agents}
- B01J 20/261: {obtained by reactions only involving carbon to carbon unsaturated bonds (macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F)}
- B01J 20/267: {Cross-linked polymers}
- B01J 20/28042: {Shaped bodies; Monolithic structures}
- B01J 20/285: based on polymers
- B01J 2220/82: Shaped bodies, e.g. monoliths, plugs, tubes, continuous beds
- G01N 2030/528: {Monolithic sorbent material}
- C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29)
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and polymerizing the mixture to form the surfactant-based monolithic column. The present disclosure also provides a surfactant-based monolithic column, a method for separating molecules, and a process for preparing a surfactant monomer.

## Claims

### Claim 1

A method for making a surfactant-based monolithic column, the method comprising:
providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen; and
polymerizing the mixture to form the surfactant-based monolithic column, wherein the at least one surfactant monomer comprises a hydrocarbon monomer having a carbon chain length ranging from about 6 to about 20, a functional head group, and a conjugated tail group, wherein the functional head group comprises a carboxylic acid group, an amino acid group, or a phosphonium group.

### Claim 2 (depends on 1)

The method of claim 1, wherein the functional head group comprises the amino acid group.

### Claim 3 (depends on 1)

The method of claim 1, wherein the at least one surfactant monomer comprises 11-acrylamidoundecanoic acid, 6-acrylamido-hexanoic acid, 7-acrylamido-heptanoic acid, 17-acrylamido-hepatadecanoic acid, 18-acrylamido-octadecanoic acid, 19-acrylamido-nonadecanoic acid, 20-acrylamido-eicosanoic acid, or a combination thereof.

### Claim 4 (depends on 1)

The method of claim 1, wherein the at least one surfactant monomer comprises 11-acrylamidoundecanoic acid, and wherein the at least one crosslinker comprises ethylene dimethacrylate, and wherein the at least one initiator comprises azoisobutyronitrile, and wherein the at least one porogen comprises water, 1,4-butanediol, and 1-propanol.

### Claim 5 (depends on 1)

The method of claim 1, wherein the steps of providing and polymerizing are carried out in a capillary tube.

### Claim 6 (depends on 5)

The method of claim 5, further comprising vinylizing the capillary tube before the steps of providing and polymerizing.

### Claim 7 (depends on 1)

The method of claim 1, wherein the mixture further comprises at least one copolymer monomer and the step of polymerizing comprises copolymerizing the at least one surfactant monomer and the at least one copolymer monomer.

### Claim 8 (depends on 1)

The method of claim 1, wherein the at least one surfactant monomer is present in the mixture in an amount ranging from about 0.5% (w/w) to about 7% (w/w).

### Claim 9 (depends on 1)

The method of claim 1, wherein the at least one porogen comprises water, 1,4-butanediol, and 1-propanol, and wherein the water is present in the mixture in an amount ranging from about 2% (w/w) to about 12% (w/w), and wherein the 1,4-butanediol is present in the mixture in an amount ranging from about 0% (w/w) to about 12% (w/w), and wherein the 1-propanol is present in the mixture in an amount ranging from about 60% (w/w) to about 74% (w/w).

### Claim 10

A method for making a surfactant-based monolithic column, the method comprising:
providing a mixture comprising at least one surfactant monomer, at least one copolymer monomer, at least one crosslinker, at least one initiator, and at least one porogen; and
polymerizing the mixture to (i) copolymerize the at least one surfactant monomer and the at least one copolymer monomer, and (ii) form the surfactant-based monolithic column, wherein the at least one surfactant monomer comprises a hydrocarbon monomer having a carbon chain length ranging from about 6 to about 20, a functional head group, and a conjugated tail group, wherein the functional head group comprises a carboxylic acid group, an amino acid group, or a phosphonium group.