# US 10,118,921 B2 · Diarylmethylidene piperidine derivatives and their use as delta opoid receptor agnists

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- Number: US 10,118,921 B2
- Document ID: US10118921B2
- Status: Granted
- Kind: B2
- Application number: 15/535,464
- Filed: 2015-12-17
- Published: 2017-11-16
- Granted: 2018-11-06
- Earliest claimed: 2014-12-19
- Assignees: Pharmnovo AB
- Applicants: Pharmnovo AB
- Inventors: Bengt Von Mentzer; Ingemar Starke; Peter Brandt
- Web page: https://patentgrep.com/patent/US10118921B2

## CPC

- C07D 417/06: linked by a carbon chain containing only aliphatic carbon atoms
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- C07D 401/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound of formula I, for use in pain therapy and a pharmaceutical composition comprising said compound.

## Claims

### Claim 1

A compound of formula I
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

A method for treating a pain condition in a patient in need thereof comprising administering a therapeutically effective amount of the compound of formula I or a pharmaceutically acceptable salt thereof according to claim 1 to the patient to treat the pain condition.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the pain condition is directed towards acute pain.

### Claim 4 (depends on 2)

The method according to claim 2, wherein the pain condition is directed towards chronic pain.

### Claim 5 (depends on 4)

The method according to claim 4, wherein the pain condition is directed towards chronic joint pain.

### Claim 6 (depends on 4)

The method according to claim 4, wherein the pain condition is directed towards chronic joint pain caused by osteoarthritis or fibromyalgia.

### Claim 7 (depends on 1)

A pharmaceutical composition comprising at least a therapeutically effective amount of the compound of the formula I or a pharmaceutically acceptable salt thereof according to claim 1 as an active ingredient together with a pharmaceutically acceptable carrier.

### Claim 8 (depends on 7)

A method for treating pain comprising the step of administering the composition according to claim 7 to a patient in need thereof to treat pain.

### Claim 9 (depends on 8)

The method according to claim 8, wherein the pain is acute or chronic pain.

### Claim 10 (depends on 8)

The method according to claim 8, wherein the pain is chronic joint pain.

### Claim 11 (depends on 8)

The method according to claim 8, wherein composition is administered via at least one of oral, topical, parenteral, intravenous, intramuscular, subcutaneous, intra articular injection, buccal, sublingual, rectal, vaginal, transdermal, nasal or inhalation.

### Claim 12 (depends on 8)

The method of claim 8, wherein the therapeutically effective amount of compound of the formula I or physiologically acceptable salt thereof is from 0.0001-100 mg/kg body weight of the patient.

### Claim 13 (depends on 8)

The method of claim 8, wherein the therapeutically effective amount of compound of the formula I or physiologically acceptable salt thereof is from 0.01-10 mg/kg body weight of the patient.