# US 10,118,827 B2 · Combustion synthesis of calcium phosphate constructs and powders doped with atoms, molecules, ions, or compounds > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,118,827 B2 - Document ID: US10118827B2 - Status: Granted - Kind: B2 - Application number: 14/275,641 - Filed: 2014-05-12 - Published: 2014-11-13 - Granted: 2018-11-06 - Earliest claimed: 2013-05-10 - Applicants: Reed A. Ayers; Nina L. Vollmer - Inventors: Reed A. Ayers; Nina L. Vollmer - Web page: https://patentgrep.com/patent/US10118827B2 ## CPC - C01B 25/32: Phosphates of magnesium, calcium, strontium, or barium - A61L 27/12: Phosphorus-containing materials, e.g. apatite - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - B01D 39/2068: {Other inorganic materials, e.g. ceramics} - A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates - A61L 2300/104: Silver, e.g. silver sulfadiazine - A61L 2430/02: for reconstruction of bones; weight-bearing implants - C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C} - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28) ## Abstract The invention relates to a synthetic bone material and a process for making the same. The synthetic bone material may comprise multiple phases of calcium phosphate. Another aspect of the invention is a porous filter, and the method of making the same, and wherein the porous filter is substantially similar to the process for forming the synthetic bone material. ## Claims ### Claim 1 A method of producing a synthetic bone graft material, comprising: mixing a calcium source and a phosphorus source to form a mixture, wherein the calcium source is selected from the group consisting of calcium oxide, calcium carbonate, calcium hydroxide, calcium fluoride, calcium nitrate, and combinations thereof, and wherein the phosphate source is selected from the group consisting of phosphorous pentoxide, phosphate (PO43−), pyrophosphate, compounds thereof, and combinations thereof; forming the mixture into a pellet: and providing an ignition source to the pellet in an inert atmosphere to form the synthetic bone graft material, wherein an ignition temperature is less than about 100° C. ### Claim 2 (depends on 1) The method of claim 1, wherein a material of the synthetic bone graft material comprises at least one calcium orthophosphate. ### Claim 3 (depends on 1) The method of claim 1, wherein the mixture comprises: between about 0.5 to about 0.6 parts of the calcium source; and between about 0.4 to about 0.5 parts of the phosphorous source. ### Claim 4 (depends on 1) The method of claim 1, wherein a ratio of the calcium source to phosphorous source in the mixture is about 0.54:about 0.46. ### Claim 5 (depends on 1) The method of claim 1, wherein the mixing occurs in air. ### Claim 6 (depends on 1) The method of claim 1, wherein the mixing occurs in an inert environment, and wherein an inert gas of the inert environment is selected from the group consisting of argon, nitrogen, helium, and combinations thereof. ### Claim 7 (depends on 1) The method of claim 1, further comprising at least one additive of collagen, immunofluorescence label, alginate, chitosan coatings, BMPs, VEGF, allograft bone, xenograft bone, tissue and protein. ### Claim 8 (depends on 1) The method of claim 1, wherein the ignition source is at least one of a laser, a hot wire, an oven, a furnace, a flame, a torch, Joule heating, a hot press, a chemical catalyst, a chemical reaction and combinations thereof. ### Claim 9 (depends on 1) The method of claim 1, wherein the calcium source is a powder. ### Claim 10 (depends on 1) The method of claim 1, wherein the phosphate source is a powder. ### Claim 11 (depends on 1) The method of claim 1, wherein the calcium source is the calcium oxide, and wherein the phosphorus source is the phosphorous pentoxide. ### Claim 12 (depends on 1) The method of claim 1, further comprising heating the synthetic bone graft material at a temperature of between about 25° C. and 1300° C. ### Claim 13 (depends on 1) The method of claim 1, wherein a force applied to the mixture to form the pellet is between about 1 psi and about 80 psi. ### Claim 14 (depends on 1) The method of claim 1, wherein the mixture is pressed into a mold to form the pellet. ### Claim 15 (depends on 14) The method of claim 14, wherein a load of less than about 5000 metric tons of pressure is applied to the mold. ### Claim 16 (depends on 1) The method of claim 1, further comprising mixing the mixture with a dopant. ### Claim 17 (depends on 16) The method of claim 16, wherein the dopant is at least one of Mg, Sr, Sn, silver, gold, copper, zinc, and silver nitrate. ### Claim 18 (depends on 16) The method of claim 16, wherein the dopant is an antimicrobial agent. ### Claim 19 (depends on 1) The method of claim 1, further comprising mixing the calcium source and the phosphorous source with a dopant in an inert environment. ### Claim 20 (depends on 19) The method of claim 19, wherein the mixture comprises: between about 50% by weight and about 60% by weight of the calcium source; between about 40% by weight and about 50% by weight of the phosphorous source; and between about 0.005% by weight and about 30% by weight of the dopant.