# US 10,118,171 B2 · Ion-exchange composition comprising a complex of support particles, dispersant, and electrostatically bound layering particles

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- Number: US 10,118,171 B2
- Document ID: US10118171B2
- Status: Granted
- Kind: B2
- Application number: 14/814,451
- Filed: 2015-07-30
- Published: 2017-02-02
- Granted: 2018-11-06
- Earliest claimed: 2015-07-30
- Assignees: Dionex Corporation
- Applicants: Dionex Corporation
- Inventors: Laurence A. Woodruff; Christopher A. Pohl; Jeffrey S. Rohrer
- Web page: https://patentgrep.com/patent/US10118171B2

## CPC

- B01J 43/00: Amphoteric ion-exchange, i.e. using ion-exchangers having cationic and anionic groups; Use of material as amphoteric ion-exchangers; Treatment of material for improving their amphoteric ion-exchange properties (ion-exchange chromatography processes B01D15/36)
- B01D 15/363: {Anion-exchange}
- B01J 41/05: in the strongly basic form
- B01J 41/09: Organic material
- B01J 41/20: Anion exchangers for chromatographic processes
- B01J 47/016: Modification or after-treatment of ion-exchangers
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)

## Abstract

An ion-exchange composition suitable for use in ion exchange chromatography, comprising neutral vinyl polymer support particles irreversibly bound to a dispersant having ionizable sites which are un-ionized at a neutral pH and which are ionized under highly acidic or highly basic conditions, and fine layering particles functionalized with ion-exchanging sites on the surfaces thereof. A portion of the ionizable sites are ionized and bound electrostatically to a portion of the fine layering particles ion-exchanging sites, producing a support particle-dispersant-fine layering particle complex.

## Claims

### Claim 1

A method of producing an ion-exchange composition suitable for use in ion exchange chromatography, said method comprising the steps of:
(a) forming a first complex of neutral vinyl polymer support particles irreversibly bound to a dispersant, said dispersant having ionizable sites which are un-ionized at a neutral pH and which are ionized under highly basic or highly acidic conditions and said dispersant selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, and polyacrylamide,
(b) packing the first complex into a chromatography column,
(c) forming a mixture of said first complex with an aqueous slurry of fine layering particles, functionalized with ion-exchanging sites on the surfaces of said fine layering particles, at said highly basic or highly acidic conditions so that said dispersant includes said ionized sites, and
(d) electrostatically binding said dispersant ionized sites to a portion of said fine particle ion-exchanging sites to produce a support particle-dispersant-fine layering particle complex.

### Claim 2 (depends on 1)

The method of claim 1 in which said highly basic conditions are at a pH of at least 12 and said highly acidic conditions are at a pH of less than 3.

### Claim 3 (depends on 1)

The method of claim 1 in which said dispersant is a polyvinyl alcohol with alcohol groups deprotonated to produce said ionized sites.