# US 10,118,020 B2 · Devices and methods for endovascular access and therapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,118,020 B2 - Document ID: US10118020B2 - Status: Granted - Kind: B2 - Application number: 13/844,319 - Filed: 2013-03-15 - Published: 2013-10-24 - Granted: 2018-11-06 - Earliest claimed: 2011-12-07 - Assignees: Traumatek Solutions, B.V. - Applicants: Itzhak Avneri; Ben-Ami Avneri; Shahar Avneri; Lior Avneri - Inventors: Itzhak Avneri; Ben-Ami Avneri; Shahar Avneri; Lior Avneri - Web page: https://patentgrep.com/patent/US10118020B2 ## CPC - A61M 25/0133: {Tip steering devices} - A61B 17/12031: {complete occlusion} - A61B 17/12109: {in a blood vessel} - A61M 25/065: {Guide needles} - A61M 25/09041: {Mechanisms for insertion of guide wires} - A61B 17/12136: {Balloons} - A61B 17/1214: {Coils or wires} - A61B 17/12168: {having a mesh structure (A61B17/1214 takes precedence)} - A61B 46/10: specially adapted for instruments{, e.g. microscopes} - A61B 2017/00022: {Sensing or detecting at the treatment site} - A61B 2090/064: {for measuring force, pressure or mechanical tension} - A61M 25/0127: {Magnetic means; Magnetic markers} - A61M 2025/0024: {Expandable catheters or sheaths} - A61M 2025/1052: {for temporarily occluding a vessel for isolating a sector} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract The present invention provides for devices and methods for providing endovascular therapy, including facilitating establishment of vascular access, placement of endovascular sheaths, catheter tip localization, and administration of vascular occlusion. The invention includes a vessel cannulation device, an expandable sheath, an occlusion catheter, and a localizer each of which may be provided separately or used as part of a system. One embodiment of the invention is a vessel cannulation device including: a housing having a distal end with a distal tip and a proximal end; a guidewire lumen passing through the housing and at least the distal tip; a sensor coupled to the guidewire lumen; and an advancing member, which is configured for advancing at least one of a guidewire or a sheath and which is operably coupled to the sensor. ## Claims ### Claim 1 A vessel cannulation device comprising: a housing having a distal end with a distal tip and a proximal end, the distal tip of the housing being configured to penetrate a vessel; a lumen passing through at least the distal tip; a sensor coupled to the lumen, the sensor being configured to sense a physiologic parameter; and a blunting device advancing member configured for advancing a blunting device, wherein the blunting device is operably coupled to the sensor, and wherein the blunting device advancing member is configured to advance the blunting device in response to the sensor sensing the physiologic parameter within a predetermined range, wherein a response time is a period of time between when the distal tip penetrates the vessel and when the blunting device advancing member finishes advancing, wherein the device is configured to minimize the response time to be in a predetermined range of time, and wherein the predetermined range of the physiologic parameter correlates to a particular location. ### Claim 2 (depends on 1) The vessel cannulation device of claim 1, wherein the sensor is a membrane. ### Claim 3 (depends on 2) The vessel cannulation device of claim 2, wherein the membrane is a pressure operable diaphragm. ### Claim 4 (depends on 2) The vessel cannulation device of claim 2, wherein the membrane is elastic. ### Claim 5 (depends on 1) The vessel cannulation device of claim 1, further comprising a fluid passageway coupled to the sensor. ### Claim 6 (depends on 5) The vessel cannulation device of claim 5, wherein the fluid passageway is at least partially pre-filled with a biologically acceptable fluid. ### Claim 7 (depends on 5) The vessel cannulation device of claim 5, wherein fluid entering the fluid passageway increases pressure in the fluid passageway thereby causing movement of the sensor which in turn engages the blunting device advancing member and thereby advances the blunting device. ### Claim 8 (depends on 1) The vessel cannulation device of claim 1, wherein the sensor is in direct contact with fluid. ### Claim 9 (depends on 1) The vessel cannulation device of claim 1, wherein the response time is between 0.02-1 seconds. ### Claim 10 (depends on 1) The vessel cannulation device of claim 1, wherein the response time is between 0.05-0.5 seconds. ### Claim 11 (depends on 1) The vessel cannulation device of claim 1, wherein the blunting device advances automatically in response to the sensor detecting the physiologic parameter. ### Claim 12 (depends on 1) The vessel cannulation device of claim 1, wherein the predetermined range of the physiologic parameter is above 20 mm Hg. ### Claim 13 (depends on 1) The vessel cannulation device of claim 1, wherein the predetermined range of the physiologic parameter is about 5 mm Hg to about 20 mm Hg. ### Claim 14 (depends on 1) The vessel cannulation device of claim 1, wherein the physiologic parameter is blood pressure. ### Claim 15 (depends on 1) The vessel cannulation device of claim 1, wherein the sensor is not dependent on creation of negative pressure within the device. ### Claim 16 (depends on 1) The vessel cannulation device of claim 1, wherein the particular location is one of a vein and an artery. ### Claim 17 (depends on 1) The vessel cannulation device of claim 1, wherein the predetermined range of the physiologic parameter is a controllable predetermined range. ### Claim 18 (depends on 1) The vessel cannulation device of claim 1, wherein the sensor is one of a pressure sensor, a conductivity sensor, a flow sensor, an ultrasonic sensor, a photoelectric sensor, and a resistance sensor. ### Claim 19 A method for providing a vessel cannulation, the method comprising the steps of: placing a vessel cannulation device having a housing having a distal end with a distal tip and a proximal end in close proximity of a vessel, the distal tip of the housing being configured to penetrate the vessel and the vessel cannulation device configured to receive fluid; advancing the vessel cannulation device until the distal tip of the housing of the vessel cannulation device pierces the vessel allowing the fluid to pass through a lumen in at least the distal tip; sensing a physiologic parameter by a sensor coupled to the lumen; and advancing a blunting device with a blunting device advancing member in response to the sensor sensing the physiologic parameter within a predetermined range, wherein the blunting device is operably coupled to the sensor; wherein a response time is a period of time between when the distal tip penetrates the vessel and when the blunting device advancing member finishes advancing, wherein the device is configured to minimize the response time to be in a predetermined range of time, and wherein the predetermined range of the physiologic parameter correlates to a particular location. ### Claim 20 (depends on 19) The method of claim 19, wherein the sensor is in direct contact with the fluid. ### Claim 21 (depends on 19) The method of claim 19, wherein the sensor is coupled to a fluid passageway. ### Claim 22 (depends on 21) The method of claim 21, wherein the fluid passageway is partially pre-filled with a biologically acceptable fluid. ### Claim 23 (depends on 19) The method of claim 19, wherein the vessel is an artery and the physiologic parameter is pressure and wherein the sensor senses when the predetermined range is above about 20 mm Hg. ### Claim 24 (depends on 19) The method of claim 19, wherein the vessel is a vein and the physiologic parameter is pressure and wherein the sensor senses when the predetermined range is between about 5 mm Hg to about 20 mm Hg. ### Claim 25 (depends on 19) The method of claim 19, wherein the response time is between 0.02-1 seconds. ### Claim 26 (depends on 19) The method of claim 19, wherein the response time is between 0.05-0.5 seconds. ### Claim 27 (depends on 19) The method of claim 19, wherein the sensor is not dependent on creation of negative pressure within the device.