# US 10,118,016 B2 · Microvascular obstruction detection and therapy

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- Number: US 10,118,016 B2
- Document ID: US10118016B2
- Status: Granted
- Kind: B2
- Application number: 15/256,272
- Filed: 2016-09-02
- Published: 2016-12-22
- Granted: 2018-11-06
- Earliest claimed: 2006-08-02
- Assignees: Osprey Medical, Inc.
- Applicants: Osprey Medical, Inc.
- Inventors: Robert S. Schwartz; Robert A. Van Tassel
- Web page: https://patentgrep.com/patent/US10118016B2

## CPC

- A61M 25/007: {Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked}
- A61B 5/02007: {Evaluating blood vessel condition, e.g. elasticity, compliance}
- A61B 5/0215: by means inserted into the body
- A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
- A61B 8/00: Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B 8/06: Measuring blood flow
- A61M 25/10: Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00})
- A61M 25/1011: {Multiple balloon catheters}
- A61M 37/0092: {using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis}
- A61M 2025/0002: {with a pressure sensor at the distal end}
- A61M 2025/0003: {having an additional lumen transmitting fluid pressure to the outside for measurement}
- A61M 2025/1052: {for temporarily occluding a vessel for isolating a sector}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A method of detecting and treating a microvascular obstruction is provided. In one embodiment, a catheter is provided for both detecting the microvascular obstruction and treating or removing the obstruction.

## Claims

### Claim 1

A system for treating a thrombotic or spasmodic obstruction in microvasculature with a treatment agent, the system comprising:
an injector;
an expandable occlusion member;
an intravascular treatment catheter at least partially surrounded by the expandable occlusion member, the intravascular treatment catheter comprising a proximal portion in fluid communication with the injector, said intravascular treatment catheter comprising at least two lumens in communication with the proximal portion, and a distal diffusion portion, wherein the at least two lumens comprise:
a first lumen configured to deliver inflation medium from the proximal portion of the intravascular treatment catheter to the expandable occlusion member disposed at a distal portion of the intravascular treatment catheter so as to selectively inflate and deflate the expandable occlusion member, said expandable occlusion member being positioned proximal to the distal diffusion portion of the intravascular treatment catheter; and
a second lumen configured to fluidly communicate delivery of the treatment agent from the injector to the distal diffusion portion of the treatment catheter, said distal diffusion portion defining a plurality of small holes located distally of the expandable occlusion member, and configured to diffuse the treatment agents into the vasculature;
wherein the distal tip of the intravascular treatment catheter comprises a distal port in communication with the second lumen to allow passage of a guidewire to position the intravascular catheter in the vasculature, said distal port being configured to allow passage of the guidewire through the distal tip, but sufficiently restrict the injection of treatment agent out of the distal port; and
a sensor for monitoring the status of thrombotic or spasmodic occlusion of the microvasculature.

### Claim 2 (depends on 1)

The system of claim 1, wherein the plurality of small holes are configured so as to allow infusion and extraction of medium and a thrombotic material therethrough.

### Claim 3 (depends on 1)

The system of claim 1, wherein the sensor comprises a distal port at said distal portion of the treatment catheter.

### Claim 4 (depends on 1)

The system of claim 1, wherein the sensor comprises a pressure transducer at the distal portion of the intravascular treatment catheter.

### Claim 5 (depends on 1)

The system of claim 1, wherein the at least two lumens include a third lumen, wherein the third lumen contains a proximal sensor configured to measure a pressure or a flow from the distal portion of the intravascular treatment catheter to a proximal portion of the intravascular treatment catheter.

### Claim 6 (depends on 1)

The system of claim 1, wherein the sensor comprises a flow sensor.

### Claim 7 (depends on 1)

The system of claim 1, wherein the sensor comprises an ultrasonic sensor.

### Claim 8 (depends on 1)

The system of claim 1, further comprising an ultra sound emitter configured to facilitate a dissolution of the thrombotic or spasmodic obstruction.

### Claim 9 (depends on 1)

The system of claim 1, further comprising the guide wire.