Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions
AssigneeArrow International, Inc.
InventorsJun Li, Zheng Zhang, Chad C. Huval, Michael A. Bouchard, Christopher R. Loose, Arthur J. Coury
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Abstract
A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
Claims14
A process for grafting a polymer from an article comprising a substrate having a surface, a bulk beneath the surface, and a near-surface zone lying between the surface and the bulk, the process comprising incorporating a polymerization initiator into the near-surface zone and graft polymerizing a polymer from the substrate surface to form a grafted polymer layer comprising the grafted polymer, the grafted polymer layer having a global average dry thickness that is at least equal to the global average Rrms surface roughness of the substrate surface and at least about 50 nanometers.
Dependencies are inferred from the claim text.