Methods of using water-soluble inorganic compounds for implants
AssigneeOrthomedex LLC
InventorJames A. Walls
Life of this patent
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Abstract
A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.
Claims45
A method comprising:
- selecting an implant possessing a poorly-soluble matrix material having a physically continuous interconnected matrix as a porous structure disposed on at least a portion of the outer surface of the implant and defining interstices within the porous structure;
- blending water-soluble inorganic material within at least some of the interstices of the porous structure, the water-soluble inorganic material including at least one bioactive agent, wherein at least a majority of the water-soluble inorganic material is particles having dimensions below 100 microns and wherein the interstices of the porous structure have average dimensions ranging from 100 to about 1,000 microns;
- attaching the water-soluble inorganic material within the interstices to form the composition of the implant;
- and
- placing the implant carrying the composition in proximity of tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biological desirable voids within said interstices into which tissue can grow to assist fixation of the implant within the patient.
A method comprising:
- selecting an implant having a roughened or textured surface treatment creating pits, craters or surface irregularities on at least a portion of the outer surface of the implant, wherein water-soluble inorganic particles are blended and at least one of fused by heat or fixed by utilizing at least one of (i) a biodegradable polymer, (ii) a biocompatible adhesive, and (iii) a biocompatible material, within at least some of the pits, craters or surface irregularities of the roughened or textured surface to provide at least one of non-antibiotic antimicrobial and osteoinductive implant properties during the dissolution of the water-soluble inorganic particles;
- and
- placing the implant carrying the composition in proximity of tissue so that as the water-soluble inorganic particles dissolve at a predetermined rate and biological desirable voids within the pits, craters and surface irregularities are created into which tissue can grow to assist fixation of the implant within the patient.
A method of creating biologically desirable voids on at least a portion of the outer surface of an implant, comprising:
- selecting at least one water-soluble inorganic material having at least a first average particle dimension and a selected dissolution rate;
- selecting a poorly-water-soluble matrix material having a physically continuous porous structure on at least a portion of the outer surface of the implant and defining interstices within the porous structure, wherein the first average particle dimension is selected to be smaller than the average dimension of the interstices;
- blending the water-soluble inorganic material within at least some of the interstices of the porous structure;
- attaching the water-soluble inorganic material within at least some of the interstices of the porous structure to form the composition;
- and
- placing the implant carrying composition into a patient in proximity to tissue so that the water-soluble inorganic material progressively dissolves at a predetermined rate to generate biologically desirable voids by gradually exposing more of the interstices into which tissue can then grow to assist fixation of the implant within the patient.
Dependencies are inferred from the claim text.