# US 10,117,962 B2 · Antipathogenic compositions

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- Number: US 10,117,962 B2
- Document ID: US10117962B2
- Status: Granted
- Kind: B2
- Application number: 14/390,053
- Filed: 2013-03-13
- Published: 2016-03-17
- Granted: 2018-11-06
- Earliest claimed: 2012-04-03
- Assignees: Servico Group Oy
- Applicants: Ozics Oy
- Inventors: Auvo Kaikkonen; Juha-Pekka Nuutinen; Andreas Posel
- Web page: https://patentgrep.com/patent/US10117962B2

## CPC

- A61L 24/0015: {Medicaments; Biocides}
- A61L 24/0089: {containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084}
- A61L 27/446: {with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61M 5/31596: {comprising means for injection of two or more media, e.g. by mixing}
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2400/06: Flowable or injectable implant compositions
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

Compositions useful as bone fillers or dental composites are provided which may include a sterilizing agent.

## Claims

### Claim 1

A syringe having a first compartment, a second compartment, a plunger and a static mixer whereby depressing the plunger forces ingredients from the first compartment and the second compartment through the static mixer and outside of the syringe
wherein the first compartment includes one or more polymerizable compounds, one or more glass filler compounds, one or more sterilizing agents, one or more polymerization accelerators, one or more calcium phosphate precipitating compounds and one or more free-radical scavenger compounds; and
wherein the second compartment includes one or more polymerizable compounds, one or more glass filler compounds, one or more sterilizing agents, one or more polymerization initiators, one or more calcium phosphate precipitating compounds and one or more free-radical scavenger compounds, wherein the one or more sterilizing agents is glutaraldehyde present in an amount between about 2.0 wt % and about 2.5 wt %.

### Claim 2 (depends on 1)

The syringe of claim 1 wherein the one or more polymerizable compounds includes an acrylate compound.

### Claim 3 (depends on 2)

The syringe of claim 2 wherein the acrylate compound includes one or more of bis-phenol A glycidyl dimetharcylate, ethoxylated bis-phenol A dimethacrylate or triethylene glycol dimethacrylate.

### Claim 4 (depends on 1)

The syringe of claim 1 wherein the one or more glass filler compounds includes one or more of barium boroalumina silicate or fumed silica.

### Claim 5 (depends on 1)

The syringe of claim 1 wherein the one or more sterilizing agents further includes one or more of organic acids, benzoic acid, scorbic acid, organic esters, parabens, methyl, ethyl, propyl and butyl esters of para-(4)-hydroxy benzoic acid, quaternary ammonium compounds, biguanides, chlorhexidine, chlorhexidine diacetate, chlorhexidine gluconate, organomercurial compounds, phenylmercuric nitrate, phenyl mercuric acetate, phenyl mercuric acid, merthiolate, alcohols, ethanol, methanol, propan-1-ol, propan-2-ol, phenyl ethanol, aldehyde compounds, formaldehyde, glyoxal, malonaldehyde, succinaldehyde, adipaldehyde, halogen compounds, iodine, iodine compounds, iodophors, chlorine, chlorine compounds, chlorine releasing compounds, calcium hypochlorite, sodium dichloroisocyanusate, hypochlorous acid, mercuric chloride, benzalkonium chloride, cetylpyridinium chloride, hydrogen peroxide, peroxy acids, peracetic acid, peroxygens, propiolactone, β-propiolactone, peracetic acid, cupric ascrobate, sodium hypochlorite, sodium thioglycolate, phenol, cresol, or chlorocresol.

### Claim 6 (depends on 1)

The syringe of claim 1 wherein the one or more polymerization initiators includes benzoyl peroxide.

### Claim 7 (depends on 1)

The syringe of claim 1 wherein the one or more polymerization accelerators includes dimethyl-p-toluidine.

### Claim 8 (depends on 1)

The syringe of claim 1 wherein the one or more free-radical scavenger compounds includes butylated hydroxytoluene.

### Claim 9 (depends on 1)

The syringe of claim 1 wherein the one or more sterilizing agents is stable without the use of a separate stabilizing compound.

### Claim 10 (depends on 1)

The syringe of claim 1 wherein the one or more sterilizing agents consists essentially of glutaraldehyde.

### Claim 11 (depends on 1)

The syringe of claim 1 wherein the calcium phosphate precipitating compound is hydroxyapatite.