Virus-like particle conjugates for diagnosis and treatment of tumors
AssigneesAura Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsElisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
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Abstract
The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
Claims22
A tumor-targeting papilloma virus-like particle comprising about 50 to about 500 near infrared phthalocyanine dye molecules conjugated to papilloma virus capsid proteins, wherein the near infrared phthalocyanine dye molecules become toxic or produce a toxic molecule upon light activation.
A method, comprising:
- administering, to a subject having an ocular tumor, a tumor-targeting papilloma virus-like particle comprising about 50 to about 1000 photosensitive molecules that become toxic or produce a toxic molecule upon light activation.
Dependencies are inferred from the claim text.