# US 10,117,935 B2 · Adsorption of fluorinated anesthetics within the pores of molecular crystals

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- Number: US 10,117,935 B2
- Document ID: US10117935B2
- Status: Granted
- Kind: B2
- Application number: 15/534,923
- Filed: 2015-12-10
- Published: 2017-12-28
- Granted: 2018-11-06
- Earliest claimed: 2014-12-11
- Assignees: University of Houston System
- Applicants: University of Houston System
- Inventors: Ognjen Miljanic; Teng-Hao Chen; Watchareeya Kaveevivitchai
- Web page: https://patentgrep.com/patent/US10117935B2

## CPC

- A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A61K 31/02: Halogenated hydrocarbons
- A61K 31/08: acyclic, e.g. paraformaldehyde
- A61P 23/00: Anaesthetics
- B01D 53/02: by adsorption, e.g. preparative gas chromatography {(solid sorbent compositions B01J20/00, preparation of inorganic compounds or elements C01)}
- C07D 231/16: Halogen atoms or nitro radicals
- B01D 2253/20: Organic adsorbents
- B01D 2257/2066: Fluorine
- B01D 2259/4533: for medical purposes
- Y02P 20/151: Reduction of greenhouse gas [GHG] emissions, e.g. CO2
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- Y02P: CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

## Abstract

A method of delivering or sequestering anesthetic agents by adsorption of such agents by porous partially fluorinated compounds which display high weight adsorption capacities.

## Claims

### Claim 1

A method of binding an anesthetic agent comprising:
contacting a gas comprising an anesthetic agent with a non-covalent organic framework comprising a compound of:
wherein said compound forms a porous supramolecular structure; and
adsorbing said anesthetic agent within the pores of a compound of Formula 1.

### Claim 2 (depends on 1)

The method of claim 1, further comprising delivering said anesthetic agent to a patient in need thereof.

### Claim 3 (depends on 2)

The method of claim 2, further comprising sequestering said anesthetic agent from a said patient.

### Claim 4 (depends on 3)

The method of claim 3, wherein said sequestering occurs post operatively.

### Claim 5 (depends on 3)

The method of claim 3, wherein said sequestering occurs during an operative procedure.

### Claim 6 (depends on 3)

The method of claim 3, wherein said sequestering reduces toxicity.

### Claim 7 (depends on 3)

The method of claim 3 wherein said sequestering reduces post-operative stress.

### Claim 8 (depends on 1)

The method of claim 1, wherein said framework has a weight adsorption capacity of about 50% to about 75% for said anesthetic agent.

### Claim 9 (depends on 1)

The method of claim 1, wherein said framework has a weight adsorption capacity of about 60 to about 65% for said anesthetic agent.

### Claim 10 (depends on 5)

The method of claim 5, wherein said anesthetic agents comprise fluorinated anesthetics, non-fluorinated anesthetics or a combination thereof.

### Claim 11 (depends on 1)

The method of claim 1, wherein the anesthetics comprise sevoflurane, enflurane, isoflurane, methoxyflurane, desflurane, halothane, or combinations thereof.