# US 10,117,901 B2 · Prophylactic or therapeutic agent for peptic ulcer, food additive for prophylactic or therapeutic use, iNOS expression inhibitor and COX-2 expression inhibitor

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- Number: US 10,117,901 B2
- Document ID: US10117901B2
- Status: Granted
- Kind: B2
- Application number: 15/524,522
- Filed: 2015-11-06
- Published: 2017-11-09
- Granted: 2018-11-06
- Earliest claimed: 2014-11-07
- Assignees: Euglena Co., Ltd.
- Applicants: euglena Co., Ltd.
- Inventors: Eriko Yoshida; Yuta Asayama; Osamu Iwata; Ayaka Nakashima; Kengo Suzuki; Misa Ohgushi; Naoki Harada; Yoshihisa Nakano
- Web page: https://patentgrep.com/patent/US10117901B2

## CPC

- A61K 35/68: Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
- A61K 31/716: Glucans
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided are a prophylactic or therapeutic agent for a peptic ulcer, a food additive for prevention and treatment of a peptic ulcer, an iNOS expression inhibitor, and a COX-2 expression inhibitor, all of which have little side effects. The prophylactic or therapeutic agent contains a Euglena-derived material as an active ingredient. The Euglena-derived material may be Euglena, paramylon, or an acid-treated paramylon. The prophylactic or therapeutic agent is useful for the prevention or treatment of a peptic ulcer induced by psychological stress. The peptic ulcer may be a gastric ulcer. The food additive contains a Euglena-derived material as an active ingredient.

## Claims

### Claim 1

A method for treatment of a peptic ulcer, comprising:
administering a composition comprising a Euglena as an active ingredient to a patient in need thereof.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said peptic ulcer is a peptic ulcer induced by psychological stress.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the peptic ulcer is a gastric ulcer.