# US 10,117,898 B2 · Platelet lysate gel

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- Number: US 10,117,898 B2
- Document ID: US10117898B2
- Status: Granted
- Kind: B2
- Application number: 15/667,538
- Filed: 2017-08-02
- Published: 2017-11-16
- Granted: 2018-11-06
- Earliest claimed: 2011-11-23
- Assignees: Cell Therapy Limited
- Applicants: Cell Therapy Limited
- Inventors: Thomas Averell Houze; Martin John Evans; Ajan Reginald; Ina Laura Pieper
- Web page: https://patentgrep.com/patent/US10117898B2

## CPC

- A61K 35/19: Platelets; Megacaryocytes
- A61K 8/042: {Gels}
- A61K 8/19: containing inorganic ingredients
- A61K 8/27: Zinc; Compounds thereof
- A61K 8/43: Guanidines
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/447: {containing sulfur}
- A61K 8/4913: {having five membered rings, e.g. pyrrolidone carboxylic acid}
- A61K 8/4946: {Imidazoles or their condensed derivatives, e.g. benzimidazoles}
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/72: containing organic macromolecular compounds
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/96: containing materials, or derivatives thereof of undetermined constitution
- A61K 8/983: {Blood, e.g. plasma}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0031: {Rectum, anus}
- A61K 9/0034: {Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants}
- A61K 35/12: Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells (vaccines or medicinal preparations containing antigens or antibodies A61K39/00)
- A61K 35/16: Blood plasma; Blood serum (umbilical cord blood A61K35/51)
- A61K 35/33: Fibroblasts
- A61L 26/0019: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds}
- A61L 26/0023: {Polysaccharides}
- A61L 26/0061: {Use of materials characterised by their function or physical properties}
- A61L 26/008: {Hydrogels or hydrocolloids}
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 15/02: for disorders of the vagina
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61Q 19/08: Anti-ageing preparations
- C12N 5/0644: {Platelets; Megakaryocytes}
- A61K 2800/524: Preservatives
- A61L 2300/30: Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

The invention concerns a pharmaceutical composition comprising a platelet lysate and its use to treat a wound, an anal fissure, vaginal atrophy or a wrinkle.

## Claims

### Claim 1

A method of treating a wound, an anal fissure, vaginal atrophy or a wrinkle in a human patient in need thereof, comprising administering to the human patient a therapeutically effective amount of human platelet lysate produced by subjecting a population of human platelets to four freeze-thaw cycles, wherein the freeze portion of each cycle is carried out at a temperature lower than or equal to −190° C.

### Claim 2

A method of treating a wound, an anal fissure, vaginal atrophy or a wrinkle in a human patient in need thereof, comprising (a) producing human platelet lysate by subjecting a population of human platelets to four freeze-thaw cycles, wherein the freeze portion of each cycle is carried out at a temperature lower than or equal to −190° C., and (b) administering to the patient a therapeutically effective amount of the platelet lysate produced in (a).