# US 10,117,890 B2 · Methods and compositions for treating pain

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- Number: US 10,117,890 B2
- Document ID: US10117890B2
- Status: Granted
- Kind: B2
- Application number: 15/376,281
- Filed: 2016-12-12
- Published: 2017-08-10
- Granted: 2018-11-06
- Earliest claimed: 2012-02-11
- Assignees: Academia Sinica
- Applicants: Academia Sinica
- Inventors: Chih-Cheng Chen; Yun-Lian Lin; Jim-Min Fang; Yijuang Chern; Chia-Ching John Lin; Wei-Nan Chen; Chun-Jung Lin
- Web page: https://patentgrep.com/patent/US10117890B2

## CPC

- A61K 31/7076: containing purines, e.g. adenosine, adenylic acid
- A61K 36/8988: Gastrodia
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 29/02: without antiinflammatory effect
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Methods for treating pain such as fibromyalgia, comprising administering to a subject in need thereof an effective amount of an adenosine analog, wherein the adenosine analog may be a compound of Formula (I): (I), or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising the adenosine analog for use in treating pain (e.g., fibromyalgia), optionally further comprising Substance P (SP), are also provided.

## Claims

### Claim 1

A method for treating fibromyalgia, comprising administering to a subject in need thereof an effective amount of an adenosine analog, wherein the adenosine analog is a compound of Formula (II):
or a pharmaceutically acceptable salt thereof,
wherein R3 is hydroxymethyl (HOCH2);
n is 1, 2 or 3; and
R4 is an unsubstituted phenyl or a phenyl substituted with a hydroxyl, a halogen group, or both.

### Claim 2 (depends on 1)

The method of claim 1, wherein the adenosine analog is T1-11:
or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 1)

The method of claim 1, wherein the adenosine analog is JMF1998:
or a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 1)

The method of claim 1, wherein the adenosine analog is JMF2665:
or a pharmaceutically acceptable salt thereof.

### Claim 5 (depends on 1)

The method of claim 1 further comprising administering the subject Substance P (SP).

### Claim 6

A method for treating fibromyalgia, comprising administering to a subject in need thereof an effective amount of an adenosine analog, wherein the adenosine analog is JMF 1907:
or a pharmaceutically acceptable salt thereof.

### Claim 7 (depends on 6)

The method of claim 6, further comprising administering the subject Substance P (SP).

### Claim 8

A pharmaceutical composition, comprising therapeutically effective amounts of an adenosine analog and Substance P (SP), wherein the adenosine analog is JMF1907 or a compound of Formula (I):
or a pharmaceutically acceptable salt thereof,
wherein:
X is O;
R1 is —NH(CH2)nR4;
R2 is hydrogen (H);
R3 is hydroxymethyl (HOCH2);
n is 1, 2 or 3; and
R4 is a phenyl and wherein the phenyl is optionally substituted with a hydroxyl, and/or a halogen group, or both.